Zyceva 150mg Tablet

About

Zyceva 150mg Tablet is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) specifically indicated for the treatment of certain types of non-small cell lung cancer (NSCLC) and pancreatic cancer. This targeted therapy works by selectively binding to the intracellular domain of the EGFR, thereby inhibiting the tyrosine kinase activity associated with the receptor. In many cancers, particularly NSCLC with activating EGFR mutations, the EGFR pathway is overactive, promoting uncontrolled cell growth, proliferation, angiogenesis, and metastasis. By blocking this crucial signaling pathway, Zyceva effectively disrupts the cellular processes that drive tumor progression. This leads to a reduction in tumor growth and improved patient outcomes, especially in individuals whose tumors harbor specific EGFR mutations, offering a personalized and often more tolerable treatment alternative compared to conventional chemotherapy. Its oral administration provides convenience while requiring careful monitoring for specific side effects.

Uses

• Treatment of non-small cell lung cancer (NSCLC) with activating EGFR mutations.
• Maintenance therapy for advanced NSCLC.
• Treatment of pancreatic cancer in combination with gemcitabine.
• Used in patients who have failed prior chemotherapy regimens.

Directions For Use

Take orally once daily on an empty stomach, at least one hour before or two hours after food. Follow physician's instructions carefully.

Benefits

• Targeted therapy for specific cancer types.
• Oral administration offers convenience for patients.
• Can improve progression-free survival in EGFR-mutated NSCLC.
• May lead to significant tumor response rates.
• Alternative for patients intolerant to or failing chemotherapy.
• Generally well-tolerated compared to traditional chemotherapy.

Side Effects

• Rash (acneiform, pruritic)
• Diarrhea (can be severe)
• Nausea and vomiting
• Fatigue
• Anorexia
• Dry skin
• Conjunctivitis/keratoconjunctivitis
• Interstitial lung disease (ILD) (rare but serious)
• Liver function abnormalities
• Nail disorders (paronychia)
• Hair changes
• Gastrointestinal perforation (rare)

Safety Measures

• Alcohol - Limit or avoid alcohol as it may exacerbate gastrointestinal side effects and potentially increase liver enzyme elevations.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Women of childbearing potential must use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may be excreted in breast milk and could harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Generally does not require dose adjustment for renal impairment, but caution is advised in severe cases.
• Lung - Monitor closely for new or worsening pulmonary symptoms (e.g., dyspnea, cough, fever) as interstitial lung disease is a rare but serious side effect.

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