Abcixirel 10mg Injection

About

Abcixirel 10mg Injection contains Abciximab, a glycoprotein IIb/IIIa receptor antagonist. It is a potent antiplatelet agent used in conjunction with aspirin and heparin to prevent ischemic cardiac complications in patients undergoing percutaneous coronary intervention (PCI), such as angioplasty or stent placement. Abciximab works by blocking the glycoprotein IIb/IIIa receptors on the surface of platelets, which are crucial for platelet aggregation and thrombus formation by binding fibrinogen and von Willebrand factor. This inhibition prevents the final common pathway of platelet aggregation, thereby reducing the risk of acute coronary events like myocardial infarction or urgent revascularization. Its potent and rapid antiplatelet effect is critical during and immediately after PCI to maintain vessel patency and prevent re-occlusion, significantly improving patient outcomes in high-risk procedures.

Uses

• Prevention of ischemic complications during PCI.
• Adjunct to PCI for unstable angina or non-Q-wave MI.
• Reduction of risk of MI and death in high-risk PCI patients.
• Used with aspirin and heparin for optimal effect.

Directions For Use

Administer intravenously as a bolus followed by a continuous infusion, as directed by a physician. Close monitoring for bleeding is essential.

Benefits

• Significantly reduces ischemic complications during PCI.
• Decreases risk of myocardial infarction.
• Prevents acute stent thrombosis.
• Improves outcomes in high-risk coronary patients.
• Potent and rapid antiplatelet effect.
• Reduces need for urgent revascularization.

Side Effects

• Major and minor bleeding (e.g., gastrointestinal, retroperitoneal)
• Thrombocytopenia (low platelet count)
• Bradycardia (slow heart rate)
• Hypotension (low blood pressure)
• Nausea
• Vomiting
• Headache
• Back pain
• Injection site reactions
• Allergic reactions
• Pseudoaneurysm
• Pericardial effusion

Safety Measures

• Alcohol - Avoid alcohol as it may increase the risk of bleeding.
• Pregnancy - Use only if clearly indicated and benefits outweigh potential risks to the fetus.
• Breastfeeding - Not recommended; it is unknown if it passes into breast milk and could harm the infant.
• Liver - Use with extreme caution in severe hepatic impairment due to increased bleeding risk.
• Kidney - Use with caution in severe renal impairment due to increased bleeding risk.
• Lung - No specific contraindications, but monitor for signs of allergic reactions affecting respiration.

Disclaimer

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