Absun 250mg Tablet

About

Absun 250mg Tablet contains Abiraterone acetate, a crucial medication for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This drug functions as a potent inhibitor of the enzyme cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), which plays a pivotal role in the biosynthesis of androgens in the testes, adrenal glands, and prostate tumor tissue. By effectively blocking CYP17, Abiraterone significantly reduces the production of androgens, which are known to fuel the growth of prostate cancer cells. This reduction in androgen levels helps to slow disease progression and improve patient outcomes.

Administered orally, Abiraterone is typically prescribed in conjunction with a corticosteroid like prednisone or prednisolone to mitigate the risk of mineralocorticoid excess, a potential side effect resulting from CYP17 inhibition. It has demonstrated significant clinical benefits, including improved overall survival and progression-free survival, in patients with advanced prostate cancer that has become resistant to conventional hormone therapies. Careful monitoring of blood pressure, serum potassium, and liver function tests is essential throughout the treatment period to ensure patient safety and optimize therapeutic efficacy.

Uses

• Metastatic castration-resistant prostate cancer (mCRPC)
• Metastatic high-risk castration-sensitive prostate cancer (mCSPC)
• Prostate cancer progression after androgen deprivation therapy
• Hormone-sensitive prostate cancer (in combination with ADT)

Directions For Use

Take orally on an empty stomach, at least one hour before or two hours after food. Administer with prednisone/prednisolone as directed by your doctor.

Benefits

• Potently inhibits androgen synthesis.
• Extends overall survival in advanced prostate cancer.
• Delays time to chemotherapy initiation.
• Oral formulation for ease of use.
• Effective in patients resistant to prior therapies.
• Provides a targeted hormonal therapy option.

Side Effects

• Fatigue
• Peripheral edema
• Hypertension
• Hypokalemia
• Elevated liver enzymes
• Diarrhea
• Urinary tract infection
• Hot flashes
• Arthralgia (joint pain)
• Cardiac events (e.g., heart failure)
• Adrenal insufficiency
• Hyperglycemia

Safety Measures

• Alcohol - Avoid alcohol as it may increase the risk of liver toxicity and other adverse effects, potentially interfering with treatment efficacy.
• Pregnancy - Abiraterone is contraindicated in pregnant women due to potential harm to the fetus. Women of childbearing potential should avoid handling this medication without gloves.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after the last dose, as the drug may pass into breast milk and harm the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are often required. Close and regular monitoring of liver function tests is critical.
• Kidney - Use with caution in patients with renal impairment. No specific dose adjustment is typically needed for mild-to-moderate impairment, but monitoring is advised.
• Lung - Monitor for signs of pulmonary toxicity, though less common, especially in patients with pre-existing lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.