Acotrexed 100mg Injection

About

Acotrexed Injection contains Methotrexate, a potent antimetabolite and antifolate agent with broad applications in oncology and immunology. Its primary mechanism of action involves inhibiting dihydrofolate reductase, a key enzyme vital for the synthesis of purine nucleotides and thymidylate, which are fundamental building blocks for DNA and RNA synthesis. This inhibition effectively disrupts cellular proliferation, making it highly effective against rapidly dividing cancer cells. In addition to its critical role in treating various cancers such as leukemia, lymphoma, and certain solid tumors, methotrexate is also a cornerstone in the management of severe autoimmune diseases like rheumatoid arthritis and psoriasis, owing to its significant immunosuppressive and anti-inflammatory properties. It can be administered via multiple routes, including intravenously, intramuscularly, subcutaneously, or intrathecally, depending on the specific clinical indication and dosage.

Uses

• Acute lymphoblastic leukemia (ALL)
• Rheumatoid arthritis
• Psoriasis
• Breast cancer

Directions For Use

Administered by a healthcare professional via intravenous, intramuscular, subcutaneous, or intrathecal routes. Dosage and frequency vary significantly based on the indication and patient's condition.

Benefits

• Effective in treating various types of cancer.
• Reduces inflammation and disease progression in autoimmune conditions.
• Available in multiple administration routes.
• Well-established safety profile with proper monitoring.
• Can induce remission in certain leukemias.
• Reduces joint damage in rheumatoid arthritis.

Side Effects

• Nausea and vomiting
• Stomatitis/mucositis
• Myelosuppression (leukopenia, thrombocytopenia, anemia)
• Fatigue
• Hair loss (alopecia)
• Liver enzyme elevation
• Kidney dysfunction
• Skin rash
• Diarrhea
• Headache
• Dizziness
• Photosensitivity

Safety Measures

• Alcohol - Strictly avoid alcohol due to increased risk of hepatotoxicity, a significant side effect of methotrexate.
• Pregnancy - Contraindicated in pregnancy due to severe teratogenic effects. Effective contraception is mandatory for both male and female patients during and for a specified period after treatment.
• Breastfeeding - Not recommended during breastfeeding as methotrexate is excreted in breast milk and can cause serious adverse effects in the infant.
• Liver - Use with extreme caution in patients with liver disease. Regular monitoring of liver function tests is crucial, and dose adjustments or discontinuation may be necessary.
• Kidney - Excreted primarily by the kidneys. Use with caution in renal impairment; dose reduction is often required to prevent toxicity. Monitor kidney function closely.
• Lung - Can cause acute or chronic interstitial pneumonitis. Monitor for respiratory symptoms like cough, dyspnea, or fever, and discontinue if lung toxicity is suspected.

Disclaimer

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