Acozacit 100mg Injection

About

Acozacit 100mg Injection contains Azacitidine, a pyrimidine nucleoside analog that exhibits potent antineoplastic activity. It is primarily utilized in the treatment of myelodysplastic syndromes (MDS) and certain types of acute myeloid leukemia (AML), particularly in patients who are not candidates for intensive chemotherapy. Its mechanism of action involves hypomethylation of DNA and direct cytotoxicity to abnormal hematopoietic cells in the bone marrow. By inhibiting DNA methyltransferases, azacitidine can restore normal gene function critical for cellular differentiation and proliferation, thereby improving hematopoiesis. This leads to a reduction in the number of abnormal cells, can improve blood counts, and potentially prolong survival in eligible patients. The drug is administered via subcutaneous injection or intravenous infusion, typically in cycles, under strict medical supervision.

Uses

• Myelodysplastic syndromes (MDS)
• Acute myeloid leukemia (AML) in certain patient populations
• Chronic myelomonocytic leukemia (CMML)
• Juvenile myelomonocytic leukemia (JMML)

Directions For Use

Administered by a healthcare professional via subcutaneous injection or intravenous infusion. Dosage and schedule are determined by the treating physician based on the patient's condition.

Benefits

• Improves overall survival in high-risk MDS.
• Delays progression to AML in MDS patients.
• Reduces transfusion dependence.
• Enhances quality of life for some patients.
• Offers a treatment option for elderly AML patients.
• Modulates gene expression through hypomethylation.

Side Effects

• Nausea and vomiting
• Diarrhea or constipation
• Fatigue and weakness
• Injection site reactions (redness, pain)
• Fever
• Anemia
• Thrombocytopenia
• Neutropenia
• Loss of appetite
• Headache
• Dizziness
• Muscle pain

Safety Measures

• Alcohol - Avoid alcohol consumption as it may exacerbate certain side effects like nausea or liver toxicity, and can interact with other medications.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Effective contraception is required for both male and female patients during and after treatment.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Dose adjustments may be necessary, and liver function should be monitored regularly.
• Kidney - Use with caution in patients with renal impairment. Dose adjustments may be required, and kidney function should be closely monitored throughout treatment.
• Lung - Rarely, interstitial lung disease has been reported. Monitor for new or worsening respiratory symptoms.

Disclaimer

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