ALOJA 25 10S

About

Losartan is an angiotensin receptor blocker (ARB) primarily used to treat essential hypertension, commonly known as high blood pressure, in adult patients. Its therapeutic action involves selectively blocking the binding of angiotensin II to the AT1 receptors found in various tissues, including vascular smooth muscle. Angiotensin II is a potent vasoconstrictor and a key component of the renin-angiotensin-aldosterone system (RAAS), which plays a crucial role in blood pressure regulation. By inhibiting angiotensin II's effects, Losartan promotes vasodilation, reduces peripheral vascular resistance, and consequently lowers blood pressure.

Beyond hypertension, it is also prescribed to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. Additionally, Losartan is indicated for the treatment of diabetic nephropathy in patients with type 2 diabetes and a history of hypertension, where it helps to slow the progression of kidney disease by reducing proteinuria. This comprehensive action makes it a valuable medication for managing cardiovascular and renal health.

Uses

• Treatment of hypertension (high blood pressure)
• Reduction of stroke risk in high-risk patients
• Management of diabetic nephropathy in type 2 diabetes
• Treatment of heart failure (off-label use)

Directions For Use

Take orally once daily, with or without food, as directed by your physician. Do not crush or chew the tablet.

Benefits

• Effectively lowers high blood pressure
• Reduces the risk of stroke
• Protects kidney function in diabetic patients
• Well-tolerated with a low incidence of cough
• Provides cardiovascular protection
• Helps manage heart failure symptoms

Side Effects

• Dizziness
• Fatigue
• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels)
• Renal impairment
• Back pain
• Muscle cramps
• Diarrhea
• Nasal congestion
• Upper respiratory tract infection
• Angioedema (rare, severe allergic reaction)
• Headache

Safety Measures

• Alcohol - Alcohol may increase the hypotensive effect of Losartan; use with caution and avoid excessive intake.
• Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to potential fetal harm. Consult your doctor immediately if pregnant.
• Breastfeeding - Not recommended during breastfeeding as Losartan may pass into breast milk. Discuss alternatives with your doctor.
• Liver - Use with caution in patients with severe hepatic impairment; dosage adjustment may be necessary.
• Kidney - Use with caution in patients with renal impairment; regular monitoring of kidney function is advised.
• Lung - Generally safe for patients with lung conditions; does not typically cause the cough associated with ACE inhibitors.

Disclaimer

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