ETERNEX M 1000MG 10

About

ETERNEX M 1000MG contains Metformin hydrochloride, a widely used oral antidiabetic medication belonging to the biguanide class. It is prescribed for the management of type 2 diabetes mellitus, particularly in individuals who are overweight or obese. Metformin's primary actions include reducing glucose production by the liver, decreasing glucose absorption from the gastrointestinal tract, and enhancing insulin sensitivity in peripheral tissues, thereby improving glucose uptake and utilization. These mechanisms collectively lead to a significant reduction in both fasting and postprandial blood glucose levels. Metformin is often the first-line pharmacological treatment for type 2 diabetes due to its efficacy, favorable safety profile (low risk of hypoglycemia when used alone), and potential cardiovascular benefits. It is used in conjunction with diet and exercise to achieve optimal glycemic control.

Uses

• Treatment of type 2 diabetes mellitus.
• Improvement of glycemic control in adults.
• Used as an adjunct to diet and exercise.
• Management of insulin resistance.

Directions For Use

Take orally, usually once or twice daily, with meals to minimize gastrointestinal side effects, or as directed by your healthcare provider.

Benefits

• Significant reduction in blood glucose.
• Improved cellular response to insulin.
• Decreased glucose output from the liver.
• Helps manage weight in diabetic patients.
• Low risk of hypoglycemia as monotherapy.
• Potential for long-term cardiovascular protection.

Side Effects

• Diarrhea
• Nausea
• Abdominal bloating
• Vomiting
• Metallic taste
• Anorexia
• Headache
• Dizziness
• Vitamin B12 deficiency
• Skin rash
• Weakness
• Lactic acidosis (rare, serious)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, a rare but life-threatening complication, and may also lower blood sugar levels.
• Pregnancy - Generally not recommended during pregnancy. Consult your doctor to discuss the risks and benefits, and consider insulin as a safer alternative.
• Breastfeeding - Metformin is excreted into breast milk in small amounts. Consult your doctor to weigh the potential risks to the infant against the benefits of treatment for the mother.
• Liver - Contraindicated in severe hepatic impairment due to a significantly increased risk of lactic acidosis. Use with caution in patients with any degree of liver dysfunction.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment is required for moderate renal impairment to prevent accumulation and lactic acidosis.
• Lung - Generally considered safe for use in patients with stable lung conditions. No specific contraindications related to pulmonary function.

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