About
Valsartan/Hydrochlorothiazide is a combination medication prescribed for the management of essential hypertension. Valsartan functions as an angiotensin II receptor blocker (ARB), selectively inhibiting the AT1 receptor. This action prevents angiotensin II from causing vasoconstriction and stimulating aldosterone release, leading to systemic vasodilation and a reduction in blood pressure. Hydrochlorothiazide (HCTZ), a thiazide diuretic, acts on the distal convoluted tubules of the kidneys to inhibit sodium and chloride reabsorption, promoting increased excretion of sodium, chloride, and water. This reduction in extracellular fluid volume contributes to its antihypertensive effect. The synergistic mechanisms of valsartan and HCTZ provide a more potent and sustained reduction in blood pressure compared to either agent used alone, making it an effective option for patients requiring more comprehensive blood pressure control.
Uses
- Treatment of essential hypertension.
- Management of fluid retention and edema associated with heart failure.
- Blood pressure control in patients unresponsive to monotherapy.
- Reduction of cardiovascular risk in hypertensive patients.
Directions For Use
Take this medication orally, usually once daily, with or without food, as directed by your physician.
Benefits
- Effectively lowers high blood pressure through dual mechanisms.
- Provides sustained blood pressure control with once-daily dosing.
- Reduces fluid retention and swelling.
- Offers enhanced efficacy compared to single-agent therapy.
- Helps reduce the risk of stroke and heart attack.
- Generally well-tolerated with a low incidence of cough.
Side Effects
- Dizziness
- Headache
- Fatigue
- Nausea
- Orthostatic hypotension
- Hyperkalemia (less common with HCTZ)
- Hypokalemia (due to HCTZ)
- Dehydration
- Muscle cramps
- Increased uric acid levels
- Photosensitivity
- Rash
Safety Measures
- Alcohol - Alcohol can potentiate the hypotensive effect of this medication, increasing the risk of dizziness or fainting. Avoid excessive intake.
- Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to fetal toxicity from the ARB component. Consult a doctor immediately if pregnant.
- Breastfeeding - Not recommended during breastfeeding as both components can pass into breast milk and may pose risks to the infant. A doctor should assess the risk-benefit.
- Liver - Use with caution in patients with severe hepatic impairment, as the diuretic component may precipitate hepatic coma.
- Kidney - Contraindicated in patients with anuria. Use with caution and monitor kidney function closely in patients with severe renal impairment or renal artery stenosis.
- Lung - Generally safe for use in patients with lung conditions, though caution is advised in patients with a history of allergy to sulfonamide-derived drugs (HCTZ).
Disclaimer
MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.
Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
| Shipping Cost |
|
| Shop Location | Assam, India |
No comments found for this product. Be the first to comment!