About
Valsartan/Amlodipine is a fixed-dose combination medication indicated for the treatment of essential hypertension. Valsartan, an angiotensin II receptor blocker (ARB), works by selectively blocking the binding of angiotensin II to the AT1 receptor, thereby inhibiting its vasoconstrictive and aldosterone-secreting effects. This results in vasodilation and a reduction in blood pressure. Amlodipine, a dihydropyridine calcium channel blocker (CCB), relaxes vascular smooth muscle by inhibiting calcium ion influx, leading to peripheral vasodilation and a further decrease in blood pressure. The complementary actions of these two agents provide enhanced antihypertensive efficacy, often achieving better blood pressure control than either component alone. This combination is particularly beneficial for patients whose blood pressure is not adequately controlled by monotherapy, offering a comprehensive approach to managing hypertension and reducing associated cardiovascular risks.
Uses
- Treatment of essential hypertension.
- Blood pressure control in patients requiring multiple agents.
- Reduction of cardiovascular risk in hypertensive patients.
- Management of hypertension with co-existing angina (due to amlodipine component).
Directions For Use
Take this medication orally, usually once daily, with or without food, as prescribed by your healthcare provider.
Benefits
- Provides effective and sustained blood pressure control.
- Combines two complementary mechanisms of action for enhanced efficacy.
- Reduces the risk of cardiovascular events associated with hypertension.
- Offers convenience with a single tablet for multiple medications.
- Generally well-tolerated with a low incidence of cough.
- Suitable for patients whose blood pressure is not controlled by monotherapy.
Side Effects
- Dizziness
- Headache
- Peripheral edema
- Fatigue
- Nausea
- Flushing
- Palpitations
- Orthostatic hypotension
- Hyperkalemia (less common)
- Abdominal pain
- Muscle cramps
- Rash
Safety Measures
- Alcohol - Alcohol can increase the blood pressure-lowering effect, potentially causing dizziness or lightheadedness. Avoid excessive consumption.
- Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to fetal toxicity from the ARB component. Consult a doctor immediately if pregnant.
- Breastfeeding - Not recommended during breastfeeding due to potential risks to the infant from both components. A doctor should assess the risk-benefit.
- Liver - Use with caution in patients with mild to moderate hepatic impairment. Dosage adjustment may be necessary, especially for the amlodipine component.
- Kidney - Use with caution in patients with severe renal impairment or renal artery stenosis due to the valsartan component. Monitor kidney function closely.
- Lung - Generally safe for use in patients with lung conditions, as neither component directly affects respiratory function.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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