AMLONG-A TAB

About

Amlong-A is a fixed-dose combination therapy indicated for the treatment of essential hypertension, particularly in patients who may also benefit from beta-blockade. It contains Amlodipine, a dihydropyridine calcium channel blocker, and Atenolol, a cardioselective beta-1 adrenergic receptor blocker. Amlodipine primarily acts by relaxing the smooth muscle cells in the arterial walls, leading to peripheral vasodilation and a subsequent reduction in systemic vascular resistance and blood pressure. Atenolol reduces heart rate, myocardial contractility, and cardiac output by blocking beta-1 receptors in the heart, thereby lowering blood pressure and decreasing myocardial oxygen demand.

This combination offers a comprehensive approach to blood pressure control, addressing both vascular resistance and cardiac output. It is especially beneficial for hypertensive patients with co-existing conditions such as angina pectoris, where both blood pressure reduction and heart rate control are desirable.

Uses

• Treatment of essential hypertension.
• Management of high blood pressure with co-existing angina.
• To reduce cardiovascular risk in hypertensive patients.
• When monotherapy with either agent is insufficient.

Directions For Use

Take once daily, preferably at the same time each day. It can be taken with or without food.

Benefits

• Effective in lowering blood pressure.
• Manages both hypertension and angina.
• Reduces heart rate and workload on the heart.
• Provides sustained blood pressure control.
• Convenient once-daily dosing.
• Helps prevent cardiovascular complications.

Side Effects

• Dizziness
• Fatigue
• Bradycardia (slow heart rate)
• Cold extremities
• Nausea
• Headache
• Edema (swelling)
• Shortness of breath
• Insomnia
• Depression
• Muscle cramps
• Hypotension

Safety Measures

• Alcohol - Avoid or limit alcohol as it can increase the hypotensive effects and cause excessive dizziness.
• Pregnancy - Not recommended during pregnancy, especially in the second and third trimesters, due to potential fetal growth restriction and bradycardia.
• Breastfeeding - Both components are excreted in breast milk; use with caution, and monitor the infant for adverse effects.
• Liver - Use with caution in patients with liver impairment, as amlodipine metabolism may be affected.
• Kidney - Atenolol is primarily renally excreted; dose adjustment is necessary in patients with moderate to severe renal impairment.
• Lung - Use with caution in patients with asthma or COPD, as atenolol, even if cardioselective, can cause bronchospasm at higher doses.

Disclaimer

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