Anazol 1mg Tablet

About

Anastrozole is a potent and selective non-steroidal aromatase inhibitor. Aromatase is an enzyme found in many tissues, including breast tissue, that converts androgens into estrogens. In postmenopausal women, the primary source of estrogen is this peripheral conversion. Anastrozole works by inhibiting aromatase, thereby significantly reducing circulating estrogen levels. This reduction in estrogen is crucial in the treatment of hormone receptor-positive breast cancer, as estrogen can stimulate the growth of these cancer cells.

It is used as adjuvant therapy for early breast cancer and for the first-line treatment of advanced breast cancer in postmenopausal women, as well as for advanced breast cancer that has progressed following tamoxifen therapy. Its targeted action helps to slow or stop the progression of estrogen-dependent tumors, improving patient outcomes and disease-free survival.

Uses

• Adjuvant treatment of early hormone receptor-positive breast cancer in postmenopausal women.
• First-line treatment of hormone receptor-positive advanced breast cancer in postmenopausal women.
• Treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.
• Prevention of breast cancer in high-risk postmenopausal women (off-label).

Directions For Use

Take one tablet orally once daily, with or without food. Follow your doctor's prescribed dosage and duration precisely.

Benefits

• Effectively reduces estrogen levels in postmenopausal women.
• Slows or stops the growth of hormone-sensitive breast cancer.
• Reduces the risk of breast cancer recurrence.
• Improves disease-free survival in early breast cancer.
• Offers a treatment option for advanced breast cancer.
• Convenient once-daily oral administration.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Nausea
• Fatigue
• Headache
• Bone pain
• Vaginal dryness
• Hair thinning
• Osteoporosis
• Increased cholesterol levels
• Peripheral edema
• Rash

Safety Measures

• Alcohol - Moderate alcohol consumption is generally not contraindicated, but excessive intake may worsen hot flashes or other side effects.
• Pregnancy - Anastrozole is contraindicated in pregnant women due to its mechanism of action and potential for fetal harm.
• Breastfeeding - It is unknown if anastrozole is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants, breastfeeding is contraindicated.
• Liver - Use with caution in patients with moderate to severe hepatic impairment. No dose adjustment is typically needed for mild impairment, but monitor closely.
• Kidney - No dose adjustment is required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment.
• Lung - Generally considered safe for use in patients with lung conditions, as it does not directly affect respiratory function.

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