Apotinib 400mg Tablet

About

Apotinib 400mg Tablet is an oral targeted therapy classified as a tyrosine kinase inhibitor (TKI), primarily used in the treatment of various types of cancer, particularly those driven by specific genetic mutations or overexpression of certain growth factor receptors. It works by selectively blocking the activity of abnormal tyrosine kinases, which are enzymes that play a crucial role in cell growth, proliferation, and survival in cancer cells. By inhibiting these signaling pathways, Apotinib effectively halts or slows the growth of tumors, induces apoptosis (programmed cell death) in cancer cells, and can prevent metastasis. This targeted approach offers a more precise treatment option with potentially fewer side effects compared to conventional chemotherapy, improving outcomes for patients with specific oncogenic drivers.

Uses

• Treatment of chronic myeloid leukemia (CML).
• Management of gastrointestinal stromal tumors (GIST).
• Treatment of specific types of lung cancer.
• Therapy for certain myelodysplastic syndromes.

Directions For Use

Take one tablet orally once daily, with a meal and a full glass of water, as prescribed by your oncologist.

Benefits

• Targets specific cancer-driving pathways.
• Inhibits tumor growth and proliferation.
• Induces apoptosis in cancer cells.
• Offers a more precise treatment approach.
• Improves progression-free and overall survival.
• Convenient oral administration.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Muscle cramps
• Fluid retention (edema)
• Skin rash
• Headache
• Abdominal pain
• Myelosuppression (low blood counts)
• Elevated liver enzymes
• Cardiac dysfunction (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may exacerbate liver toxicity or gastrointestinal side effects.
• Pregnancy - Contraindicated in pregnant women due to potential for severe fetal harm.
• Breastfeeding - Contraindicated during breastfeeding as it may be excreted in human milk and harm the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; monitor liver function closely and adjust dose as needed.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be necessary.
• Lung - Monitor for new or worsening pulmonary symptoms (e.g., interstitial lung disease, pneumonitis), especially in patients with pre-existing lung conditions.

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