About
This medication is a potent and selective tyrosine kinase inhibitor that has revolutionized the treatment of several cancers. Its primary mechanism involves the inhibition of the Bcr-Abl tyrosine kinase, which is the oncogenic driver in chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Additionally, it inhibits other key receptor tyrosine kinases, including c-Kit and PDGF receptor, making it highly effective in gastrointestinal stromal tumors (GIST) and certain myelodysplastic/myeloproliferative diseases. By blocking these specific enzymes, it prevents the uncontrolled proliferation of cancer cells and induces apoptosis, thereby transforming previously fatal diseases into manageable chronic conditions for many patients. Its targeted action minimizes damage to healthy cells, offering a more favorable toxicity profile compared to conventional chemotherapy.
Uses
- Chronic myeloid leukemia (CML).
- Gastrointestinal stromal tumors (GIST).
- Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
- Myelodysplastic/myeloproliferative diseases.
Directions For Use
Take orally with a meal and a large glass of water to minimize gastrointestinal irritation. Follow the prescribed dosage and schedule strictly.
Benefits
- Highly effective in CML and GIST.
- Targeted therapy with fewer side effects than traditional chemotherapy.
- Improves survival rates significantly.
- Oral administration offers convenience.
- Can induce durable remissions.
- Reduces tumor burden effectively.
Side Effects
- Fluid retention (edema)
- Nausea
- Vomiting
- Diarrhea
- Muscle cramps
- Fatigue
- Rash
- Abdominal pain
- Myelosuppression (neutropenia, thrombocytopenia)
- Hepatotoxicity (liver damage)
- Cardiac dysfunction (rare)
- Hypothyroidism (rare)
Safety Measures
- Alcohol - Avoid or limit alcohol due to potential for increased risk of hepatotoxicity.
- Pregnancy - Contraindicated due to potential for fetal harm; effective contraception is required during treatment.
- Breastfeeding - Not recommended; discontinue breastfeeding due to potential for serious adverse reactions in the infant.
- Liver - Use with extreme caution; dose adjustments are often necessary, and regular liver function monitoring is crucial.
- Kidney - Use with caution; dose adjustments may be necessary in patients with renal impairment.
- Lung - Monitor for new or worsening pulmonary symptoms; rare cases of interstitial lung disease and pulmonary hypertension reported.
Disclaimer
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| Shop Location | Assam, India |
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