IMATIREL 400 (10.S)

About

Imatirel 400mg Tablet contains the active ingredient imatinib, an antineoplastic medication classified as a tyrosine kinase inhibitor. It is used to treat both adults and children with chronic myeloid leukaemia (CML), a type of cancer where certain abnormal white blood cells multiply uncontrollably. It is also indicated for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph-positive ALL).

Additionally, Imatirel is used to manage specific types of gastrointestinal stromal tumours (GIST), which are cancers that develop in the walls of the digestive tract and may spread to other areas of the body. The medicine is also prescribed for myelodysplastic/myeloproliferative diseases (MDS/MPD)—a group of blood disorders where certain blood cells grow abnormally—as well as hypereosinophilic syndrome (HES) and chronic eosinophilic leukaemia (CEL), conditions involving an overproduction of eosinophils, a type of white blood cell. Furthermore, it is used to treat dermatofibrosarcoma protuberans (DFSP), a rare cancer of the tissue beneath the skin marked by abnormal cell growth. Imatirel works by inhibiting the proliferation of these abnormal cells.

Do not use Imatirel if you are allergic to imatinib or any of its components. Before starting treatment, inform your doctor if you have any liver, kidney, or heart issues, thyroid disorders, or if you have had your thyroid gland removed. Let your healthcare provider know if you have a history of hepatitis B, as the medication may reactivate the virus. Be sure to report symptoms such as unusual bruising, bleeding, fever, fatigue, or confusion. Also, be aware that this medicine may affect fertility.

Uses

• Hypereosinophilic syndrome (HES)
• Chronic myeloid leukemia (CML)
• Gastrointestinal stromal tumors (GIST)
• Chronic eosinophilic leukemia (CEL)
• Myelodysplastic/myeloproliferative diseases (MDS/MPD)
• Philadelphia chromosome positive acute lymphoblastic leukemia (ph-positive ALL)
• Dermatofibrosarcoma protuberans (DFSP)

Directions for use

This medicine should be administered by a doctor or nurse. Please do not attempt to self-administer it.

Side effects
Common:

• Decreased RBC and WBC cells
• Headache
• Swelling in the face, legs, ankle and feet
• Muscle cramps and pain
• Diarrhea
• Tiredness, dizziness
• Abdominal pain
• Increased weight
• Muscle cramps and pain
• Cough, Inflammation in the nose

 Serious:

• Swelling in the body
• Hypothyroidism
• Heart failure
• GI disorders
• Liver failure

Safety Measures

Alcohol -The safety of consuming alcohol while taking Imatirel 400mg tablets is not known. It is advisable to consult your doctor for further guidance.
Pregnancy -Imatirel 400mg tablets are not safe for use during pregnancy, as they may harm the developing fetus. Inform your doctor if you are pregnant, think you might be pregnant, or are planning to conceive. It is essential to use effective birth control throughout the treatment and for at least 15 days after taking the final dose.
Breastfeeding - Breastfeeding is not advised while taking Imatirel 400mg tablets, as the medication can pass into breast milk in small amounts and may potentially harm your baby.
Liver - Imatirel 400mg tablets are not safe for use in patients with severe liver disease. In cases of severe liver impairment, dose adjustments may be required. Inform your doctor about any liver conditions before starting treatment.
Kidney - The effects of Imatirel 400mg on the kidneys are not well established. Consult your doctor for appropriate evaluation and guidance.

Disclaimer

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