IMALEK 400MG TAB 1X6

About

Imalek (Imatinib) is a potent tyrosine kinase inhibitor used in the treatment of various cancers, most notably chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It works by selectively inhibiting the activity of several tyrosine kinases, including BCR-ABL, KIT, and PDGFRA, which are crucial for the proliferation and survival of cancer cells in these specific malignancies. By blocking these aberrant signaling pathways, Imatinib effectively halts tumor growth and induces apoptosis in affected cells. Its targeted mechanism of action has revolutionized the treatment landscape for CML, transforming it from a fatal disease into a manageable chronic condition for many patients. It is administered orally, offering a convenient and effective therapeutic option.

Uses

• Chronic Myeloid Leukemia (CML).
• Gastrointestinal Stromal Tumors (GIST).
• Myelodysplastic/Myeloproliferative Diseases.
• Hypereosinophilic Syndrome and/or Chronic Eosinophilic Leukemia.

Directions For Use

Take orally with a meal and a large glass of water to minimize gastrointestinal irritation.

Benefits

• Highly effective in CML and GIST.
• Significantly improves survival rates.
• Targeted therapy with fewer systemic side effects.
• Oral administration for patient convenience.
• Induces deep and durable disease remission.
• Reduces tumor burden and disease progression.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Muscle cramps
• Fluid retention (edema)
• Rash
• Fatigue
• Headache
• Abdominal pain
• Neutropenia
• Thrombocytopenia
• Liver enzyme elevation

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to the potential for increased liver toxicity.
• Pregnancy - Contraindicated; causes fetal harm. Women of childbearing potential must use effective contraception.
• Breastfeeding - Contraindicated; excreted in breast milk with potential for serious adverse effects in the infant.
• Liver - Use with caution; dose adjustment may be required in patients with hepatic impairment.
• Kidney - Use with caution; dose adjustment may be required in patients with severe renal impairment.
• Lung - Rare but serious pulmonary toxicity, including interstitial lung disease, can occur; monitor for respiratory symptoms.

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