Veenat 400mg Tablet

About

Veenat 400mg Tablet contains Imatinib, a potent and selective tyrosine kinase inhibitor. It primarily targets the Bcr-Abl fusion protein, which is a hallmark of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Additionally, Imatinib inhibits other tyrosine kinases, including c-Kit and PDGFR, making it highly effective in treating gastrointestinal stromal tumors (GIST) and certain other rare cancers. By blocking these specific enzymes, Imatinib prevents the uncontrolled growth and proliferation of cancer cells, leading to disease remission and significantly improved survival rates. Its targeted mechanism of action represents a major advancement in the treatment of these specific malignancies.

Uses

• Treats chronic myeloid leukemia (CML)
• Manages gastrointestinal stromal tumors (GIST)
• Indicated for Philadelphia chromosome-positive ALL
• Used in certain myelodysplastic/myeloproliferative diseases

Directions For Use

Take this medication orally with a meal and a large glass of water to minimize gastrointestinal irritation. Do not crush or chew the tablet.

Benefits

• Highly effective in CML and GIST
• Offers convenient oral administration
• Significantly improves long-term survival
• Reduces disease progression
• Provides targeted cancer therapy
• Has a well-established safety profile

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Muscle cramps
• Fluid retention (edema)
• Fatigue
• Rash
• Headache
• Abdominal pain
• Myelosuppression
• Liver enzyme elevation
• Periorbital edema

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver toxicity, a known side effect of this medication.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm; effective contraception is essential for women of childbearing potential.
• Breastfeeding - Not recommended during breastfeeding due to potential for serious adverse reactions in the infant from drug excretion into milk.
• Liver - Requires careful monitoring of liver function tests; dose adjustment may be necessary in patients with hepatic impairment.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be required based on renal function.
• Lung - Can cause pulmonary toxicity, including interstitial lung disease; monitor for new or worsening respiratory symptoms.

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