Aromita 1mg Tablet

About

Anastrozole, marketed as Aromita, is a highly potent and selective non-steroidal aromatase inhibitor. Its mechanism of action involves reversibly binding to the aromatase enzyme, which is a key enzyme responsible for the conversion of adrenal androgens into estrogens in peripheral tissues, particularly in postmenopausal women. By effectively blocking this enzymatic pathway, anastrozole significantly reduces the circulating levels of estrogen. This reduction is critical in the management of hormone-receptor-positive breast cancer, as estrogen acts as a growth factor for these cancer cells. By depriving these cells of estrogen, anastrozole helps to inhibit tumor growth and progression. It is widely used as an adjuvant therapy for early breast cancer and as a treatment for advanced breast cancer in postmenopausal women, offering a targeted endocrine approach to cancer management.

Uses

• Adjuvant treatment of early breast cancer
• First-line treatment of advanced breast cancer
• Treatment of advanced breast cancer after tamoxifen
• Hormone-receptor-positive breast cancer

Directions For Use

Take one tablet orally once daily, with or without food, as prescribed by your oncologist. Do not crush or chew the tablet.

Benefits

• Reduces estrogen levels
• Inhibits tumor growth in hormone-sensitive breast cancer
• Improves disease-free survival
• Effective in postmenopausal women
• Oral administration
• Well-established efficacy

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Nausea
• Fatigue
• Headache
• Bone thinning (osteoporosis)
• Vaginal dryness
• Hair thinning
• Rash
• Weight gain
• Mood disturbances
• Peripheral edema

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but it's generally advisable to limit alcohol intake during cancer treatment.
• Pregnancy - Contraindicated in premenopausal women and during pregnancy due to potential harm to the fetus. Effective contraception is required if there is any potential for pregnancy.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if anastrozole is excreted in human milk and could harm the infant.
• Liver - Use with caution in patients with moderate to severe liver impairment. Liver function should be monitored regularly.
• Kidney - No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment.
• Lung - No specific contraindications related to lung conditions. Monitor for any new or worsening respiratory symptoms.

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