Azacamen 100mg Injection

About

Azacamen 100mg Injection is a hypomethylating agent primarily used in the treatment of myelodysplastic syndromes (MDS) and certain types of acute myeloid leukemia (AML). It works by incorporating into DNA and RNA, leading to hypomethylation of DNA. This process helps to restore normal function to genes that are involved in cell differentiation and proliferation, which may have been silenced due to abnormal methylation in cancer cells. By reversing this epigenetic modification, Azacamen can help to improve blood cell counts, reduce the need for transfusions, and potentially prolong survival in patients with these hematological malignancies. Its mechanism involves inhibiting DNA methyltransferases, enzymes responsible for adding methyl groups to DNA, thereby reactivating tumor suppressor genes and promoting cellular differentiation. This targeted action makes it a crucial therapeutic option for patients who are not candidates for intensive chemotherapy.

Uses

• Treatment of myelodysplastic syndromes (MDS).
• Management of acute myeloid leukemia (AML) in certain patients.
• Improvement of hematological parameters in bone marrow disorders.
• Reduction of transfusion dependency in specific blood conditions.

Directions For Use

Administer subcutaneously or intravenously as directed by a healthcare professional. Dosage and frequency are determined by the patient's condition and response to treatment.

Benefits

• Improves blood cell counts.
• Reduces the need for blood transfusions.
• May prolong overall survival in MDS.
• Offers a treatment option for AML patients unsuitable for intensive chemo.
• Targets abnormal DNA methylation.
• Promotes cellular differentiation.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Fatigue
• Fever
• Injection site reactions
• Anemia
• Thrombocytopenia
• Neutropenia
• Headache
• Dizziness

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate side effects like nausea or liver strain.
• Pregnancy - Not recommended during pregnancy due to potential fetal harm; effective contraception is advised for both male and female patients.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after, due to the potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with pre-existing liver impairment; dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be required, and kidney function should be regularly assessed.
• Lung - Generally safe for use in patients with lung conditions, but monitor for any new or worsening respiratory symptoms.

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