Azaplast 100mg Injection

About

Azaplast 100mg Injection is a powerful immunosuppressive and cytotoxic agent widely utilized in the prevention of organ transplant rejection and the management of severe autoimmune diseases. Its therapeutic action stems from its ability to interfere with purine synthesis, a critical process for DNA and RNA production, thereby inhibiting the proliferation of rapidly dividing cells, particularly T and B lymphocytes. By suppressing the activity and expansion of these immune cells, Azaplast effectively dampens the immune response, preventing the body from attacking transplanted organs or its own tissues in autoimmune conditions. Administered intravenously, it ensures rapid and consistent systemic delivery, making it an essential component in complex treatment regimens to maintain graft function and control chronic inflammatory processes, requiring careful monitoring due to its broad impact on cellular function.

Uses

• Prevention of organ transplant rejection.
• Treatment of severe rheumatoid arthritis.
• Management of inflammatory bowel disease (Crohn's, ulcerative colitis).
• Treatment of other severe autoimmune conditions.

Directions For Use

Administer intravenously under the direct supervision of a healthcare professional. Dosage is individualized based on patient weight, condition, and response.

Benefits

• Effectively suppresses immune system activity.
• Prevents organ rejection in transplant patients.
• Reduces inflammation in autoimmune diseases.
• Helps achieve disease remission.
• Allows for precise intravenous dosing.
• Part of long-term disease management strategies.

Side Effects

• Nausea and vomiting
• Myelosuppression (low white blood cells, platelets)
• Increased risk of infection
• Liver dysfunction
• Pancreatitis
• Hair loss
• Skin rash
• Diarrhea
• Fever
• Mouth sores
• Increased risk of certain cancers (long-term)
• Anemia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver toxicity and gastrointestinal side effects.
• Pregnancy - Use during pregnancy is generally not recommended due to potential fetal harm. Discuss risks and benefits with your doctor.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and potentially harm the infant.
• Liver - Use with extreme caution in patients with liver impairment; close monitoring of liver function is essential. Dose adjustments may be required.
• Kidney - Administer with caution in patients with renal dysfunction; dose reductions may be necessary based on kidney function.
• Lung - Monitor for signs of pulmonary toxicity, such as interstitial pneumonitis, which can be a rare but serious complication.

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