AZUVAS 10 10

About

Rosuvastatin is a potent synthetic lipid-lowering agent belonging to the statin class, specifically an HMG-CoA reductase inhibitor. It works by competitively inhibiting the enzyme HMG-CoA reductase, which is responsible for an early and rate-limiting step in cholesterol biosynthesis in the liver. This inhibition leads to a decrease in intracellular cholesterol, prompting the liver to increase the number of LDL receptors on its cell surface. Consequently, more LDL cholesterol is removed from the bloodstream, significantly lowering total cholesterol, LDL-C, and triglycerides, while also increasing HDL-C.

Rosuvastatin is widely used for the treatment of various forms of hyperlipidemia and for the primary and secondary prevention of cardiovascular events, including myocardial infarction and stroke. Its efficacy in reducing LDL-C is dose-dependent, making it a versatile option for achieving target lipid levels in diverse patient populations. It also has pleiotropic effects beyond lipid lowering, such as anti-inflammatory and plaque-stabilizing properties.

Uses

• Reduction of elevated total cholesterol, LDL-C, and triglycerides in primary hypercholesterolemia.
• Treatment of mixed dyslipidemia to improve lipid profiles.
• Prevention of major cardiovascular events in high-risk individuals.
• Slowing the progression of atherosclerosis in adults.

Directions For Use

Take once daily, with or without food, at any time of day, as directed by your physician.

Benefits

• Highly effective in lowering LDL ("bad") cholesterol.
• Significantly reduces triglyceride levels.
• Increases HDL ("good") cholesterol.
• Reduces the risk of heart attack, stroke, and other cardiovascular events.
• Slows the buildup of plaque in arteries.
• Provides comprehensive lipid management.

Side Effects

• Headache
• Muscle pain (myalgia)
• Abdominal pain
• Nausea
• Weakness (asthenia)
• Constipation
• Dizziness
• Elevated liver enzymes (transaminases)
• Increased creatine kinase (CK) levels
• Diabetes mellitus (new onset)
• Rash
• Proteinuria (protein in urine)

Safety Measures

• Alcohol - Excessive alcohol consumption can increase the risk of liver problems associated with statin use. Limit alcohol intake.
• Pregnancy - Rosuvastatin is contraindicated during pregnancy due to the potential for fetal harm. Women of childbearing potential should use effective contraception.
• Breastfeeding - Rosuvastatin is contraindicated during breastfeeding as it may be excreted in breast milk and could harm the infant.
• Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. Liver function tests should be monitored.
• Kidney - Dose adjustment may be necessary in patients with severe renal impairment. Use with caution.
• Lung - While rare, interstitial lung disease has been reported with statins. Monitor for symptoms like dyspnea, cough, and fever.

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