Benzpee 100mg Injection

About

Benzathine penicillin is a unique, long-acting formulation of penicillin G, a narrow-spectrum antibiotic within the beta-lactam class. Its primary mechanism of action involves inhibiting the synthesis of bacterial cell walls, specifically the peptidoglycan layer, which is vital for bacterial structural integrity. This disruption leads to osmotic lysis and subsequent death of susceptible bacteria. The distinctive feature of benzathine penicillin is its slow absorption from the intramuscular injection site, resulting in prolonged, low but effective concentrations of penicillin G in the bloodstream for several weeks. This sustained therapeutic effect makes it exceptionally valuable for treating chronic infections, preventing recurrent infections, and ensuring patient compliance, particularly in conditions requiring extended antibiotic coverage.

Uses

• Syphilis (primary, secondary, latent)
• Streptococcal pharyngitis
• Rheumatic fever prophylaxis
• Yaws and pinta

Directions For Use

Administer deep intramuscularly. Do not administer intravenously or intra-arterially.

Benefits

• Long-acting antibiotic effect
• Effective against susceptible bacteria
• Convenient for single-dose treatments
• Prevents rheumatic fever recurrence
• Broad spectrum against Gram-positive bacteria
• Well-established safety profile

Side Effects

• Pain at injection site
• Hypersensitivity reactions (rash, urticaria)
• Anaphylaxis
• Diarrhea
• Nausea
• Vomiting
• Candidiasis
• Pseudomembranous colitis
• Leukopenia
• Thrombocytopenia
• Seizures (rare, high doses)
• Jarisch-Herxheimer reaction

Safety Measures

• Alcohol - Generally safe to consume alcohol in moderation, but avoid if feeling unwell.
• Pregnancy - Generally considered safe for use during pregnancy when indicated.
• Breastfeeding - Considered compatible with breastfeeding; monitor infant for diarrhea or rash.
• Liver - No specific dose adjustment needed for liver impairment.
• Kidney - Use with caution in severe renal impairment; dose adjustment may be necessary.
• Lung - No specific precautions for lung conditions, but monitor for allergic reactions.

Disclaimer

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