Biramet 250mg Tablet

About

Biramet 250mg Tablet contains Bicalutamide, an antiandrogen medication primarily used in the treatment of prostate cancer. Bicalutamide is a non-steroidal antiandrogen that works by competitively binding to androgen receptors in target tissues, thereby preventing the binding of natural androgens like testosterone and dihydrotestosterone (DHT). This action inhibits the growth-promoting effects of androgens on prostate cancer cells, which are often hormone-sensitive.

By blocking androgen receptor activation, Bicalutamide effectively suppresses the androgen-dependent proliferation of prostate cancer cells. It is typically used in combination with luteinizing hormone-releasing hormone (LHRH) analogues or surgical castration to achieve maximal androgen blockade, which is a cornerstone of advanced prostate cancer management. It can also be used as monotherapy in certain situations. Its long half-life allows for once-daily dosing, contributing to patient convenience and adherence.

Uses

• Advanced Prostate Cancer
• Metastatic Prostate Cancer
• Locally Advanced Prostate Cancer
• As part of maximal androgen blockade

Directions For Use

Take one tablet orally once daily, with or without food, as directed by your physician. It should be taken at the same time each day.

Benefits

• Blocks androgen receptor activity
• Inhibits prostate cancer cell growth
• Effective in advanced prostate cancer
• Can be used in combination therapy
• Convenient once-daily dosing
• Helps manage disease progression

Side Effects

• Hot flashes
• Breast pain/tenderness
• Gynecomastia
• Nausea
• Diarrhea
• Constipation
• Fatigue
• Dizziness
• Liver enzyme elevation
• Anemia
• Rash
• Peripheral edema

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake should be avoided as it may exacerbate liver strain, a potential side effect of bicalutamide.
• Pregnancy - Bicalutamide is not indicated for use in women. It is contraindicated in pregnant women due to potential harm to a developing male fetus.
• Breastfeeding - Bicalutamide is not indicated for use in women. It is unknown if it is excreted in human milk.
• Liver - Use with caution in patients with moderate to severe hepatic impairment. Liver function tests should be monitored regularly, as liver toxicity can occur.
• Kidney - No dose adjustment is typically required in patients with renal impairment, but caution is advised in severe cases.
• Lung - Rarely, interstitial lung disease has been reported. Patients should be monitored for new or worsening respiratory symptoms.

Disclaimer

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