Caditam 20mg Tablet

About

Tamoxifen is a well-established selective estrogen receptor modulator (SERM) primarily indicated for the treatment and prevention of hormone receptor-positive breast cancer. It exerts its therapeutic effects by competitively binding to estrogen receptors in breast cancer cells, thereby blocking the proliferative actions of estrogen. This anti-estrogenic activity is crucial in inhibiting the growth of estrogen-dependent tumors and reducing the risk of cancer recurrence. Tamoxifen acts as an antagonist in breast tissue, but can have agonist effects in other tissues like the uterus and bone.

It is widely used as adjuvant therapy following surgery or radiation for early-stage breast cancer, and also in the metastatic setting. Furthermore, tamoxifen is approved for reducing the incidence of breast cancer in high-risk women and for treating ductal carcinoma in situ (DCIS). Its long-term use has significantly improved outcomes for millions of patients, making it a foundational drug in endocrine therapy for breast cancer.

Uses

• Hormone receptor-positive breast cancer
• Adjuvant therapy for early breast cancer
• Reduction of breast cancer incidence in high-risk women
• Ductal carcinoma in situ (DCIS)

Directions For Use

Take orally, usually once or twice daily, with or without food, as directed by your doctor.

Benefits

• Effective in hormone-sensitive breast cancer
• Reduces risk of cancer recurrence
• Can be used for prevention in high-risk individuals
• Oral administration for convenience
• Improves overall survival in certain patients
• Well-established safety profile over decades

Side Effects

• Hot flashes
• Nausea
• Vaginal discharge
• Fluid retention
• Fatigue
• Mood changes
• Uterine fibroids
• Endometrial cancer risk
• Blood clots (DVT, PE)
• Cataracts
• Skin rash
• Hair thinning

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake may increase liver strain. Discuss with your doctor.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Use effective contraception during and for two months after treatment.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with pre-existing liver disease; monitor liver function tests regularly.
• Kidney - Generally safe in patients with kidney conditions; no specific dosage adjustments are usually required.
• Lung - No specific lung-related precautions, but monitor for any unusual respiratory symptoms.

Disclaimer

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