CALAPTIN 40 MG TAB 30 S

About

Verapamil is a phenylalkylamine calcium channel blocker that inhibits the influx of extracellular calcium ions across the membranes of myocardial and vascular smooth muscle cells. This action leads to coronary and peripheral vasodilation, reducing myocardial oxygen demand and improving oxygen supply. In the heart, verapamil decreases myocardial contractility, slows sinoatrial (SA) and atrioventricular (AV) nodal conduction, and prolongs AV nodal refractoriness. These effects make it effective in treating hypertension, angina, and certain supraventricular arrhythmias. Its electrophysiological properties are particularly useful in controlling ventricular rate in atrial fibrillation or flutter.

The immediate-release formulation provides rapid onset of action, suitable for acute management or titration. By modulating calcium entry, verapamil helps to relax blood vessels, thereby lowering blood pressure and reducing the workload on the heart. Its ability to slow AV nodal conduction is crucial in managing rapid heart rhythms originating above the ventricles, preventing dangerously fast ventricular responses. It is a cornerstone medication in cardiovascular therapy due to its multifaceted actions.

Uses

• Management of essential hypertension.
• Treatment of chronic stable angina pectoris.
• Control of supraventricular tachyarrhythmias.
• Prophylaxis of cluster headache (off-label).

Directions For Use

Take orally, usually with food or milk, to minimize gastrointestinal upset. Follow your doctor's dosing schedule carefully.

Benefits

• Lowers blood pressure effectively.
• Reduces frequency and severity of angina attacks.
• Controls heart rate in atrial fibrillation/flutter.
• Improves myocardial oxygen supply.
• Reduces myocardial oxygen demand.
• Available in immediate and sustained-release forms.

Side Effects

• Constipation
• Dizziness
• Headache
• Nausea
• Fatigue
• Bradycardia
• Hypotension
• Peripheral edema
• Gingival hyperplasia (rare)
• Heart block (dose-dependent)
• Congestive heart failure (exacerbation)
• Rash

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can potentiate the hypotensive effects and increase dizziness.
• Pregnancy - Use during pregnancy is generally not recommended unless the potential benefits outweigh the risks. Consult a doctor.
• Breastfeeding - Verapamil is excreted into breast milk. Breastfeeding is generally not advised during treatment.
• Liver - Use with caution in patients with hepatic impairment; dose reduction may be necessary due to extensive liver metabolism.
• Kidney - Use with caution in patients with renal impairment. While not primarily renally cleared, metabolites may accumulate.
• Lung - Generally safe for use in patients with lung conditions, as it does not typically affect respiratory function.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.