LASTET INJ 100MG 5 ML VIAL

About

LASTET INJ 100MG 5 ML VIAL contains Etoposide, a semisynthetic derivative of podophyllotoxin, classified as a topoisomerase II inhibitor. This chemotherapy agent exerts its cytotoxic effects by forming a ternary complex with topoisomerase II and DNA, preventing the re-ligation of DNA strands after cleavage. This leads to an accumulation of DNA breaks, ultimately triggering apoptosis in rapidly proliferating cancer cells. Etoposide is cell cycle phase-specific, primarily acting in the late S and G2 phases. Its mechanism of action makes it highly effective against a range of solid tumors and hematologic malignancies. It is frequently used in combination chemotherapy regimens to enhance overall treatment efficacy. Due to its potential for significant myelosuppression and other adverse effects, careful dosing, administration, and patient monitoring are essential throughout the treatment course to manage toxicities effectively and optimize therapeutic outcomes.

Uses

• Treatment of small cell lung cancer
• Management of testicular cancer
• Therapy for Hodgkin's and non-Hodgkin's lymphoma
• Used in certain types of acute myeloid leukemia

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion rate are determined by the patient's condition and treatment protocol.

Benefits

• Effective against various solid tumors
• Induces apoptosis in rapidly dividing cancer cells
• Part of established combination chemotherapy regimens
• Contributes to improved remission rates
• Well-tolerated in some treatment protocols
• Offers a crucial option for refractory cancers

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Alopecia (hair loss)
• Fatigue and malaise
• Mucositis or stomatitis
• Diarrhea or abdominal pain
• Peripheral neuropathy (rare)
• Hypersensitivity reactions
• Hypotension (with rapid infusion)
• Liver enzyme elevations
• Increased risk of infections
• Anorexia

Safety Measures

• Alcohol - Avoid alcohol consumption during treatment as it may exacerbate liver toxicity and general side effects of chemotherapy.
• Pregnancy - Contraindicated. Etoposide is teratogenic and can cause severe fetal harm. Effective contraception is mandatory.
• Breastfeeding - Contraindicated. The drug is excreted in breast milk and can cause serious adverse effects in the infant.
• Liver - Use with caution in patients with hepatic impairment. Dose adjustments may be necessary based on liver function tests.
• Kidney - Use with caution in patients with renal impairment. Dose adjustments may be necessary based on creatinine clearance.
• Lung - Rare cases of interstitial pneumonitis have been reported; monitor for any new or worsening respiratory symptoms.

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