Caxfila 160mg Tablet

About

Caxfila (cefixime) 160mg tablet is a semi-synthetic, third-generation cephalosporin antibiotic. Its bactericidal action stems from its ability to interfere with bacterial cell wall synthesis. Cefixime selectively binds to penicillin-binding proteins (PBPs) located within the bacterial cell wall, which are crucial enzymes involved in the final stages of peptidoglycan synthesis. By inhibiting these enzymes, cefixime prevents the cross-linking of peptidoglycan chains, leading to a structurally compromised and osmotically unstable cell wall. This ultimately results in bacterial cell lysis and death.

It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, making it suitable for various common infections. The 160mg tablet formulation provides a convenient dosing option for adults and older children, ensuring effective treatment for conditions such as uncomplicated urinary tract infections, acute otitis media, pharyngitis, tonsillitis, and acute exacerbations of chronic bronchitis.

Uses

• Treatment of uncomplicated urinary tract infections.
• Treatment of acute otitis media.
• Treatment of pharyngitis and tonsillitis.
• Treatment of acute exacerbations of chronic bronchitis.

Directions For Use

Take orally with or without food, as directed by your doctor.

Swallow the tablet whole with water; do not crush or chew.

Benefits

• Broad-spectrum antibacterial activity.
• Effective against common respiratory and urinary pathogens.
• Convenient once or twice-daily dosing.
• Generally well-tolerated.
• Oral formulation for ease of administration.
• Useful for treating various community-acquired infections.

Side Effects

• Diarrhea.
• Nausea.
• Vomiting.
• Abdominal pain.
• Dyspepsia.
• Headache.
• Dizziness.
• Skin rash.
• Pruritus.
• Vaginitis.
• Flatulence.
• Drug fever (rare).

Safety Measures

• Alcohol - No specific contraindication with alcohol. However, it is generally advisable to avoid or limit alcohol intake during antibiotic treatment to prevent potential gastrointestinal upset.
• Pregnancy - Generally considered safe for use during pregnancy, particularly in the later trimesters, but should be used only if clearly indicated and under medical guidance.
• Breastfeeding - Excreted in small amounts in breast milk. Generally considered compatible with breastfeeding, but monitor the infant for potential gastrointestinal disturbances or rash.
• Liver - No specific dose adjustment is typically required for patients with liver impairment, as cefixime is primarily eliminated by the kidneys.
• Kidney - Dose adjustment is necessary for patients with severe renal impairment (creatinine clearance <30 mL/min) to prevent drug accumulation and potential toxicity.
• Lung - No specific contraindication or precaution for patients with pre-existing lung conditions. It is commonly prescribed for bacterial infections affecting the respiratory system.

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