Celnalid 25mg Capsule

About

Celnalid 25mg Capsule is an immunomodulatory drug (IMiD) with a complex mechanism of action that includes anti-angiogenic, anti-inflammatory, and direct anti-tumor effects. It works by modulating the immune system, enhancing the activity of natural killer (NK) cells and T-cells, and inhibiting the production of pro-inflammatory cytokines. Additionally, Celnalid interferes with the growth and survival of cancer cells by inhibiting specific signaling pathways and promoting apoptosis (programmed cell death). Its anti-angiogenic properties also contribute to its efficacy by preventing the formation of new blood vessels that tumors require for growth and metastasis.

This medication is primarily used in the treatment of various hematological malignancies, including multiple myeloma, myelodysplastic syndromes (MDS) with a specific chromosomal abnormality (deletion 5q), and certain types of lymphoma. Due to its potent immunomodulatory and teratogenic potential, Celnalid is subject to strict risk management programs to ensure safe use. Patients must adhere to prescribed dosages and schedules, and regular monitoring for side effects, particularly myelosuppression and thromboembolic events, is crucial throughout the treatment period.

Uses

• Treatment of multiple myeloma
• Management of myelodysplastic syndromes (del(5q))
• Treatment of mantle cell lymphoma
• Management of follicular and marginal zone lymphoma

Directions For Use

Take this capsule orally once daily, with water, often on a cyclical schedule. Follow your doctor's instructions precisely.

Benefits

• Induces remission in specific hematological cancers
• Possesses strong anti-angiogenic effects
• Modulates and enhances immune responses
• Reduces inflammation and cytokine production
• Can improve overall survival and quality of life
• Synergistic when combined with other therapies

Side Effects

• Neutropenia (low white blood cells)
• Thrombocytopenia (low platelets)
• Fatigue
• Diarrhea
• Skin rash
• Constipation
• Muscle cramps
• Deep vein thrombosis (DVT)
• Pulmonary embolism (PE)
• Peripheral neuropathy
• Dizziness
• Fever

Safety Measures

• Alcohol - Avoid alcohol due to increased risk of sedation and potential for liver toxicity.
• Pregnancy - Celnalid is a severe human teratogen and is absolutely contraindicated during pregnancy. Strict contraception is mandatory.
• Breastfeeding - Not recommended during breastfeeding due to the potential for serious adverse effects in the infant.
• Liver - Use with caution in patients with liver impairment; monitor liver function tests regularly.
• Kidney - Dose adjustment is often required in patients with kidney impairment; monitor renal function closely.
• Lung - Monitor for pulmonary adverse events, including interstitial lung disease or pulmonary hypertension.

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