Celoclib 125mg Capsule

About

Celoclib 125mg Capsule is a targeted anticancer agent belonging to the class of cyclin-dependent kinase (CDK4/6) inhibitors. It works by selectively blocking the activity of CDK4 and CDK6 enzymes, which play a critical role in regulating cell cycle progression. In many cancers, these kinases are overactive, leading to uncontrolled cell division. By inhibiting CDK4/6, Celoclib arrests cancer cells in the G1 phase of the cell cycle, preventing them from replicating and proliferating. This mechanism makes it particularly effective in hormone-receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer.

Celoclib is typically used in combination with endocrine therapy to enhance its efficacy, providing a synergistic effect that improves progression-free survival in eligible patients. Its targeted action aims to minimize damage to healthy cells compared to traditional chemotherapy, though careful monitoring for specific side effects, particularly myelosuppression, is essential. The treatment regimen often involves a cyclical schedule to allow for recovery from potential adverse events, ensuring patient safety and treatment continuity.

Uses

• HR+/HER2- metastatic breast cancer (first-line)
• HR+/HER2- metastatic breast cancer (after endocrine therapy)
• Certain other solid tumors (investigational)
• Advanced liposarcoma (investigational)

Directions For Use

Take this capsule orally once daily for a specific period (e.g., 21 days on, 7 days off), as directed by your physician. It can be taken with or without food.

Benefits

• Significantly improves progression-free survival
• Synergistic with endocrine therapy
• Targets specific cell cycle pathways
• Oral administration for convenience
• Delays the need for chemotherapy in some patients
• Effective in resistant hormone-sensitive cancers

Side Effects

• Neutropenia (low white blood cells)
• Fatigue
• Nausea
• Diarrhea
• Stomatitis (mouth sores)
• Hair thinning (alopecia)
• Infections
• Elevated liver enzymes
• Skin rash
• Anemia
• Thrombocytopenia (low platelets)
• Headache

Safety Measures

• Alcohol - Limit alcohol intake as it may exacerbate fatigue or contribute to liver enzyme elevations.
• Pregnancy - Celoclib is contraindicated during pregnancy due to potential for fetal harm. Effective contraception is required.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments are required in moderate to severe cases.
• Kidney - Use with caution in patients with severe kidney impairment; dose adjustments may be necessary.
• Lung - Monitor for signs of interstitial lung disease or pneumonitis, such as new or worsening respiratory symptoms.

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