Chemlet 2.5mg Tablet

About

Chemlet 2.5mg Tablet is an oral endocrine therapy primarily used in the treatment of hormone-receptor-positive breast cancer. It belongs to the class of aromatase inhibitors, which work by blocking the enzyme aromatase. Aromatase is responsible for converting androgens into estrogens in peripheral tissues, a process that fuels the growth of hormone-sensitive breast cancers in postmenopausal women. By inhibiting aromatase, Chemlet significantly reduces estrogen levels in the body, thereby depriving estrogen-dependent cancer cells of the hormones they need to grow and proliferate. This targeted hormonal approach is a crucial component of adjuvant therapy, extended adjuvant therapy, and first-line treatment for advanced or metastatic breast cancer, offering a significant advantage in preventing recurrence and improving survival rates in appropriate patient populations.

Uses

• Adjuvant treatment of early hormone-receptor-positive breast cancer
• Extended adjuvant treatment for early breast cancer after tamoxifen therapy
• First-line treatment of advanced hormone-receptor-positive breast cancer in postmenopausal women
• Treatment of advanced breast cancer after anti-estrogen therapy failure

Directions For Use

Take this tablet orally, usually once daily, with or without food. Swallow the tablet whole with a glass of water.

Benefits

• Significantly reduces estrogen levels
• Effective in hormone-receptor-positive breast cancer
• Reduces risk of cancer recurrence
• Improves overall and progression-free survival
• Oral administration for patient convenience
• Well-established efficacy in postmenopausal women

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue
• Nausea
• Headache
• Bone thinning (osteoporosis)
• Elevated cholesterol levels
• Peripheral edema
• Hair thinning
• Vaginal dryness
• Weight gain
• Dizziness

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake may exacerbate hot flashes and other side effects.
• Pregnancy - Chemlet is contraindicated in pregnancy as it can cause fetal harm. Women of childbearing potential should use effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment with Chemlet as it is unknown if the drug is excreted in human milk and could harm the infant.
• Liver - Use with caution in patients with severe hepatic impairment. Dose adjustments may be necessary, and liver function should be monitored.
• Kidney - No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal dysfunction.
• Lung - No specific lung concerns are typically associated with Chemlet; however, general monitoring for any new respiratory symptoms is always prudent.

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