About
Clopidogrel and Aspirin combination provides a potent dual antiplatelet therapy, working synergistically to prevent blood clot formation. Clopidogrel selectively inhibits ADP-mediated platelet aggregation by irreversibly modifying the platelet ADP receptor. Aspirin, on the other hand, irreversibly inhibits cyclooxygenase-1 (COX-1) enzyme, which is responsible for the production of thromboxane A2, a powerful platelet aggregator and vasoconstrictor. This combined action targets two distinct pathways of platelet activation, resulting in a more robust and comprehensive antiplatelet effect than either drug alone. This dual inhibition significantly reduces the risk of serious cardiovascular events, including heart attacks and strokes, particularly in patients with acute coronary syndrome or those undergoing percutaneous coronary intervention with stent placement.
Uses
- Prevention of atherothrombotic events in patients with acute coronary syndrome (unstable angina, NSTEMI, STEMI).
- Prevention of stent thrombosis after percutaneous coronary intervention.
- Secondary prevention of myocardial infarction and stroke in high-risk patients.
- Management of certain peripheral arterial diseases.
Directions For Use
Take once daily with or without food, as prescribed by your doctor. Do not stop taking it without medical advice. Swallow whole.
Benefits
- Potent reduction in heart attack risk.
- Significantly lowers stroke incidence.
- Provides dual antiplatelet protection.
- Prevents blood clots in high-risk individuals.
- Crucial for post-stent placement care.
- Improves long-term cardiovascular outcomes.
Side Effects
- Increased bleeding risk (e.g., GI bleeding, bruising)
- Dyspepsia
- Abdominal pain
- Nausea
- Diarrhea
- Headache
- Dizziness
- Rash
- Tinnitus (with high aspirin doses)
- Gastric ulcers
- Hemorrhagic stroke (rare)
- Thrombotic thrombocytopenic purpura (rare)
Safety Measures
- Alcohol - Avoid or limit alcohol consumption significantly, as it can markedly increase the risk of gastrointestinal bleeding when combined with aspirin and clopidogrel.
- Pregnancy - Not recommended, especially in the third trimester due to aspirin's effects on fetal circulation. Consult your doctor immediately.
- Breastfeeding - Aspirin is excreted in breast milk and clopidogrel's excretion is unknown. Generally not recommended; consult a healthcare professional.
- Liver - Use with caution in patients with severe hepatic impairment, as both drugs are metabolized by the liver and can increase bleeding risk.
- Kidney - Use with caution in patients with severe renal impairment, as aspirin can worsen kidney function and clopidogrel's metabolites may accumulate.
- Lung - Caution in patients with asthma, as aspirin can trigger bronchospasm in some individuals (aspirin-exacerbated respiratory disease).
Disclaimer
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