DAJIO 10MG TAB

About

Dapagliflozin is an oral antidiabetic medication belonging to the class of sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by blocking the reabsorption of glucose in the kidneys, leading to increased excretion of glucose in the urine. This unique mechanism helps to lower blood glucose levels independently of insulin secretion or action, making it effective even in patients with impaired insulin production. In addition to its primary role in glycemic control, dapagliflozin has demonstrated significant benefits in reducing the risk of cardiovascular death and hospitalization for heart failure in patients with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors. It also consistently shows a modest effect on weight reduction and blood pressure lowering, contributing to overall metabolic health improvement.

Uses

• Management of type 2 diabetes mellitus.
• Reduction of HbA1c levels.
• Reduction of cardiovascular risk in certain patients.
• Used as an adjunct to diet and exercise.

Directions For Use

Take one tablet orally once daily, preferably in the morning, with or without food, as directed by your physician.

Benefits

• Effective blood glucose lowering.
• Reduces HbA1c levels.
• Promotes modest weight loss.
• Lowers blood pressure.
• Reduces risk of cardiovascular death and heart failure hospitalization.
• Insulin-independent mechanism of action.

Side Effects

• Urinary tract infections
• Genital yeast infections
• Increased urination
• Dehydration
• Dizziness
• Hypotension (low blood pressure)
• Ketoacidosis (rare, but serious)
• Kidney problems (acute kidney injury)
• Back pain
• Nausea
• Flu-like symptoms
• Thirst

Safety Measures

• Alcohol - Moderate alcohol intake is generally acceptable, but excessive consumption may increase the risk of dehydration or hypotension.
• Pregnancy - Not recommended during the second and third trimesters of pregnancy due to potential adverse effects on fetal kidney development. Consult your doctor.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if dapagliflozin passes into breast milk. Discuss with your healthcare provider.
• Liver - No dose adjustment is typically needed for mild to moderate liver impairment, but use with caution in severe impairment.
• Kidney - Not recommended for use in patients with severe renal impairment (eGFR < 25 mL/min/1.73 m²) due to reduced efficacy and increased risk of adverse effects.
• Lung - Generally safe for use in patients with lung conditions. No specific precautions related to lung function are typically required.

Disclaimer

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