DAPARYL M 10/500 TAB 10 S

About

DAPARYL M 10/500 combines Dapagliflozin (10mg) and Metformin (500mg), offering a dual-action approach for the management of type 2 diabetes mellitus. Dapagliflozin, an SGLT2 inhibitor, reduces glucose reabsorption in the kidneys, leading to increased urinary glucose excretion. Metformin, a biguanide, primarily reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues. This combination provides synergistic effects, targeting multiple pathways involved in hyperglycemia, resulting in enhanced glycemic control compared to monotherapy.

The combination is particularly beneficial for patients who require more comprehensive blood sugar management, offering additional advantages such as weight reduction, blood pressure lowering, and cardiovascular protection from dapagliflozin, alongside metformin's established efficacy and safety profile. It is used as an adjunct to diet and exercise.

Uses

• Management of type 2 diabetes mellitus
• Improved glycemic control
• Adjunct to diet and exercise
• When monotherapy is insufficient

Directions For Use

Take orally, usually twice daily with meals, or as advised by your healthcare provider.

Benefits

• Enhanced blood sugar control
• Promotes modest weight loss
• Reduces blood pressure
• Improves insulin sensitivity
• Offers cardiovascular protection
• Convenient combination therapy

Side Effects

• Urinary tract infections (UTIs)
• Genital yeast infections
• Increased urination
• Nausea, vomiting, diarrhea
• Abdominal pain
• Metallic taste
• Dizziness
• Low blood pressure (hypotension)
• Lactic acidosis (rare, due to metformin)
• Vitamin B12 deficiency (long-term metformin use)
• Ketoacidosis (rare, due to dapagliflozin)
• Headache

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to an increased risk of lactic acidosis (metformin) and dehydration (dapagliflozin).
• Pregnancy - Not recommended during pregnancy. Insulin is generally preferred for glycemic control in pregnant women. Consult your doctor.
• Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk. Consult your doctor.
• Liver - Contraindicated in severe hepatic impairment due to the metformin component, which increases the risk of lactic acidosis.
• Kidney - Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73m²) due to the risk of metformin accumulation and lactic acidosis.
• Lung - No direct lung effects. However, monitor for signs of lactic acidosis (e.g., rapid breathing) which can be a serious side effect of metformin.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.