DAPAONE M 10/500

About

DAPAONE M 10/500 is a fixed-dose combination medication for type 2 diabetes, containing dapagliflozin and metformin. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that reduces glucose reabsorption in the kidneys, leading to increased urinary glucose excretion and lower blood glucose levels. Metformin, a biguanide, works by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity. This synergistic action helps to achieve comprehensive glycemic control.

This medication is indicated for adults with type 2 diabetes mellitus to improve glycemic control when diet and exercise are insufficient. Beyond its glucose-lowering effects, dapagliflozin has demonstrated cardiovascular and renal benefits, making this combination a valuable option for patients who may also have or be at risk for heart failure or chronic kidney disease, in addition to managing their blood sugar.

Uses

• Treatment of type 2 diabetes mellitus.
• As an adjunct to diet and exercise.
• To reduce the risk of cardiovascular death and hospitalization for heart failure in certain patients.
• To reduce the risk of kidney disease progression in certain patients.

Directions For Use

Take DAPAONE M 10/500 orally, usually once or twice daily with meals, as prescribed by your physician. Swallow the tablet whole.

Benefits

• Significant reduction in HbA1c levels.
• Supports weight loss.
• Lowers blood pressure.
• Reduces risk of cardiovascular events and heart failure hospitalization.
• Provides renal protection.
• Convenient combination therapy.

Side Effects

• Genital mycotic infections
• Urinary tract infections
• Increased urination
• Nausea
• Diarrhea
• Abdominal pain
• Dizziness
• Dehydration
• Hypotension
• Ketoacidosis (rare)
• Fournier's gangrene (rare)
• Lactic acidosis (rare, serious)

Safety Measures

• Alcohol - Limit alcohol intake as it can increase the risk of lactic acidosis (due to metformin) and dehydration, which can exacerbate SGLT2 inhibitor side effects.
• Pregnancy - Not recommended during the second and third trimesters of pregnancy. Consult your doctor for guidance.
• Breastfeeding - Avoid use while breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment. Metformin is contraindicated in severe hepatic dysfunction.
• Kidney - Dose adjustment or discontinuation is necessary based on eGFR. Not recommended for patients with severe renal impairment.
• Lung - Use with caution in patients with severe respiratory conditions that may predispose to hypoxia and increase the risk of lactic acidosis.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.