Dasashil 50mg Tablet

About

Dasatinib is a potent, orally available, multi-targeted tyrosine kinase inhibitor (TKI) approved for the treatment of certain types of leukemia. It works by inhibiting the activity of several key kinases, including BCR-ABL, SRC family kinases, and others involved in cell proliferation and survival. This targeted action helps to suppress the growth of cancer cells and induce apoptosis, making it particularly effective in cases where other TKIs may have failed or are not tolerated.

Its mechanism of action involves binding to both active and inactive conformations of the BCR-ABL kinase, providing a broader spectrum of activity compared to some earlier generation TKIs. This makes it a crucial therapeutic option for patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

Uses

• Treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).
• Management of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
• Used in patients resistant or intolerant to prior therapy, including imatinib.
• Effective in both chronic and accelerated/blast phases of CML.

Directions For Use

Take this medicine orally, usually once daily, with or without food, as directed by your doctor.

Swallow the tablet whole; do not crush, cut, or chew it.

Benefits

• Highly effective in treating specific leukemias.
• Works in patients resistant to other TKIs.
• Improves remission rates in CML and ALL.
• Offers a targeted approach to cancer therapy.
• Available in various strengths for dose adjustment.
• Can prolong progression-free survival.

Side Effects

• Myelosuppression (anemia, neutropenia, thrombocytopenia)
• Fluid retention (pleural effusion, pericardial effusion, pulmonary edema)
• Diarrhea
• Nausea
• Fatigue
• Headache
• Rash
• Muscle pain
• Shortness of breath
• Hemorrhage
• QT prolongation
• Hypertension

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects like liver issues or gastrointestinal upset.
• Pregnancy - Dasatinib is contraindicated in pregnancy due to potential fetal harm. Effective contraception is required for women of childbearing potential.
• Breastfeeding - Breastfeeding is not recommended during treatment with Dasatinib and for a period after the last dose, as the drug may pass into breast milk.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Regular liver function monitoring is crucial.
• Kidney - Use with caution in patients with renal impairment. No specific dose adjustment is typically required for mild to moderate impairment, but close monitoring is advised.
• Lung - Monitor for signs of pulmonary arterial hypertension or pleural effusion, as these are known side effects. Seek immediate medical attention for new or worsening respiratory symptoms.

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