DOTAMIN INJ 5ML

About

Dobutamine is a direct-acting inotropic agent primarily used in the short-term treatment of cardiac decompensation due to depressed contractility, such as in acute heart failure or cardiogenic shock. It selectively stimulates beta-1 adrenergic receptors in the heart, leading to increased myocardial contractility and stroke volume, thereby improving cardiac output without significantly increasing heart rate or peripheral vascular resistance at therapeutic doses. Its rapid onset and short half-life make it suitable for titration to achieve desired hemodynamic effects, allowing for precise control over cardiac performance. Careful monitoring of heart rate, blood pressure, cardiac rhythm, and urine output is crucial during administration to optimize therapy and manage potential adverse events, ensuring patient safety and effective hemodynamic support.

Uses

• Acute heart failure.
• Cardiogenic shock.
• Stress echocardiography.
• Low cardiac output states.

Directions For Use

Administer intravenously via continuous infusion, typically through a central line. Dosage is individualized based on patient response and hemodynamic parameters.

Benefits

• Increases cardiac contractility.
• Improves cardiac output.
• Enhances tissue perfusion.
• Relieves symptoms of heart failure.
• Rapid onset of action.
• Short half-life allows for titration.

Side Effects

• Tachycardia
• Hypertension
• Ventricular arrhythmias
• Angina pectoris
• Headache
• Nausea
• Palpitations
• Dyspnea
• Chest pain
• Hypotension (rare)
• Injection site reactions
• Eosinophilic myocarditis (rare)

Safety Measures

• Alcohol - No direct interaction; however, alcohol can exacerbate cardiac conditions, requiring caution.
• Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding - Exercise caution; it is unknown if dobutamine is excreted in human milk.
• Liver - Use with caution in severe liver impairment as metabolism may be affected.
• Kidney - Use with caution in severe renal impairment due to potential for altered drug clearance.
• Lung - Use with caution in patients with severe pulmonary hypertension as it may worsen the condition.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.