About
This medication combines Metoprolol, a selective beta-1 adrenergic blocker, and Amlodipine, a dihydropyridine calcium channel blocker. Metoprolol reduces heart rate and blood pressure by blocking beta-adrenergic receptors, decreasing the heart's workload and oxygen demand. Amlodipine works by relaxing blood vessels, which lowers blood pressure and improves blood flow to the heart. The synergistic action of these two agents provides comprehensive control over hypertension and angina.
Amlodipine primarily acts on vascular smooth muscle, causing vasodilation, while metoprolol targets cardiac function. This combination is particularly useful for patients who require more aggressive blood pressure control or who experience angina alongside hypertension, offering dual mechanisms to achieve therapeutic goals and improve cardiovascular outcomes. The fixed-dose combination also enhances patient adherence by simplifying the medication regimen.
Uses
- Management of essential hypertension.
- Treatment of chronic stable angina.
- Management of vasospastic angina (Prinzmetal's angina).
- Reduction of cardiovascular risk in high-risk patients.
Directions For Use
Take orally once daily, preferably at the same time each day, with or without food, as directed by your doctor.
Benefits
- Potent blood pressure reduction.
- Effective control of angina symptoms.
- Provides dual mechanism of action.
- Reduces risk of cardiovascular events.
- Improves patient compliance with once-daily dosing.
- Offers comprehensive cardiovascular protection.
Side Effects
- Dizziness or lightheadedness
- Fatigue or weakness
- Bradycardia (slow heart rate)
- Peripheral edema (swelling of ankles/feet)
- Headache
- Flushing
- Nausea or abdominal pain
- Palpitations
- Shortness of breath
- Gingival hyperplasia (gum overgrowth)
- Sexual dysfunction
- Rash
Safety Measures
- Alcohol - Avoid or limit alcohol as it can exacerbate blood pressure lowering and increase dizziness.
- Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus; consult a healthcare provider.
- Breastfeeding - Both components pass into breast milk; monitor infant for adverse effects.
- Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
- Kidney - Generally safe in kidney disease, but monitor closely in severe renal impairment.
- Lung - Use with caution in patients with asthma or severe COPD due to the metoprolol component.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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