About
Telmisartan and Amlodipine is a fixed-dose combination medication specifically formulated for the effective treatment of essential hypertension. Telmisartan, an angiotensin II receptor blocker (ARB), functions by selectively blocking the binding of angiotensin II to the AT1 receptor in various tissues, leading to potent vasodilation, reduced aldosterone secretion, and decreased blood pressure. Amlodipine, a dihydropyridine calcium channel blocker, inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in peripheral arterial vasodilation and a subsequent reduction in peripheral vascular resistance. The complementary mechanisms of action of these two agents provide a powerful and sustained antihypertensive effect, making this combination particularly advantageous for patients whose blood pressure is not adequately controlled with either monotherapy or for initial therapy in individuals likely to require multiple antihypertensive agents to reach their target blood pressure goals.
Uses
- Treatment of essential hypertension.
- Blood pressure control in patients not responding to monotherapy.
- Reduction of cardiovascular risk in high-risk patients.
- Management of hypertension with associated angina.
Directions For Use
Take one tablet orally once daily, with or without food, as prescribed by your healthcare provider.
Benefits
- Potent and sustained blood pressure reduction.
- Dual mechanism of action for comprehensive control.
- Reduced risk of cardiovascular events.
- Convenient once-daily dosing.
- Improved patient adherence due to combination.
- Effective for patients with resistant hypertension.
Side Effects
- Dizziness or lightheadedness
- Peripheral edema (swelling of ankles/feet)
- Headache
- Fatigue
- Nausea
- Abdominal pain
- Palpitations
- Flushing
- Cough (less common than with ACE inhibitors)
- Hypotension
- Back pain
- Muscle cramps
Safety Measures
- Alcohol - Alcohol can enhance the blood pressure-lowering effect, leading to increased dizziness or lightheadedness. Use with caution.
- Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to risk of fetal injury or death. Avoid in first trimester.
- Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and harm the infant.
- Liver - Use with caution in patients with severe hepatic impairment; dosage adjustments may be necessary.
- Kidney - Use with caution in patients with renal artery stenosis or severe renal impairment; monitor kidney function closely.
- Lung - Generally safe for use in patients with lung conditions, as it does not typically exacerbate respiratory issues.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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