Enzamed 160mg Tablet

About

Enzalutamide is an advanced androgen receptor inhibitor that functions by blocking multiple critical steps in the androgen receptor signaling pathway, which is essential for the proliferation and survival of prostate cancer cells. It effectively inhibits androgen binding to the receptor, prevents the nuclear translocation of the activated androgen receptor, and impairs its subsequent binding to DNA and gene transcription. This comprehensive mechanism of action leads to a significant decrease in the proliferation of prostate cancer cells and an increase in their apoptosis, thereby effectively slowing disease progression. It is primarily indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and non-metastatic castration-resistant prostate cancer (nmCRPC), offering a crucial therapeutic option for patients whose disease has progressed despite conventional hormone therapy.

Uses

• Metastatic castration-resistant prostate cancer (mCRPC).
• Non-metastatic castration-resistant prostate cancer (nmCRPC).
• Prostate cancer that has spread to other parts of the body.
• Prostate cancer that has progressed despite hormone therapy.

Directions For Use

Take orally as directed by your physician, usually once daily. Swallow the tablet whole; do not chew, crush, or open.

Benefits

• Slows the progression of prostate cancer.
• Extends overall survival in mCRPC patients.
• Delays time to chemotherapy initiation.
• Improves radiographic progression-free survival.
• Offers an oral treatment option.
• Targets androgen receptor signaling effectively.

Side Effects

• Fatigue
• Hot flashes
• Headache
• Hypertension
• Diarrhea
• Nausea
• Decreased appetite
• Arthralgia (joint pain)
• Back pain
• Peripheral edema
• Seizures (rare but serious)
• Falls

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects like fatigue or liver strain.
• Pregnancy - Contraindicated in pregnant women due to potential harm to the fetus. Women of childbearing potential should avoid exposure.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if the drug is excreted in human milk and could harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary based on liver function.
• Kidney - Generally safe in mild to moderate renal impairment; severe impairment may require careful monitoring.
• Lung - No specific contraindications related to lung conditions, but monitor for any new or worsening respiratory symptoms.

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