Enzavia 40mg Capsule

About

Fenofibrate is a well-established fibric acid derivative primarily indicated for the management of various forms of dyslipidemia, particularly severe hypertriglyceridemia and mixed dyslipidemia characterized by elevated triglycerides and low high-density lipoprotein (HDL) cholesterol. Its therapeutic efficacy stems from its ability to activate peroxisome proliferator-activated receptor alpha (PPARα), a nuclear receptor that regulates lipid metabolism. Activation of PPARα leads to several beneficial changes, including increased synthesis of lipoprotein lipase, an enzyme crucial for breaking down triglycerides, and a reduction in the production of very low-density lipoprotein (VLDL) particles by the liver. Concurrently, it promotes an increase in HDL cholesterol levels. Fenofibrate is a vital treatment option for patients at high risk of pancreatitis due to extremely high triglyceride levels and plays a significant role in improving the overall atherogenic lipid profile, thereby contributing to cardiovascular risk reduction.

Uses

• Treatment of severe hypertriglyceridemia.
• Management of primary hypercholesterolemia.
• Treatment of mixed dyslipidemia.
• Reduction of cardiovascular risk in patients with type 2 diabetes and dyslipidemia.

Directions For Use

Take orally once daily with a meal, or as directed by your physician. Swallow the tablet/capsule whole.

Benefits

• Significantly lowers high triglyceride levels.
• Increases beneficial HDL cholesterol.
• Reduces harmful LDL cholesterol and VLDL.
• Decreases risk of pancreatitis in severe hypertriglyceridemia.
• Improves overall lipid profile.
• May reduce cardiovascular events in specific patient groups.

Side Effects

• Abdominal pain
• Nausea
• Diarrhea
• Constipation
• Headache
• Back pain
• Elevated liver enzymes
• Myalgia (muscle pain)
• Cholelithiasis (gallstones)
• Pancreatitis (rare)
• Rhabdomyolysis (rare, especially with statins)
• Skin rash

Safety Measures

• Alcohol - Limit alcohol intake as it can increase triglyceride levels and potentially exacerbate liver side effects associated with fenofibrate.
• Pregnancy - Fenofibrate is generally not recommended during pregnancy due to insufficient data on safety. Consult a doctor to discuss alternatives.
• Breastfeeding - It is unknown if fenofibrate is excreted in human milk. Breastfeeding is generally not advised while on this medication.
• Liver - Contraindicated in patients with active liver disease or unexplained persistent liver function abnormalities. Regular monitoring of liver enzymes is essential.
• Kidney - Contraindicated in patients with severe renal impairment. Dose adjustment is necessary for moderate renal impairment.
• Lung - Generally safe for use in patients with lung conditions; however, monitor for any unexplained respiratory symptoms, though rare.

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