Epialfa 10mg Injection

About

Epialfa 10mg Injection is a synthetic analogue of vitamin D, specifically alfacalcidol, designed to effectively regulate calcium and phosphate metabolism within the body. Unlike native vitamin D, alfacalcidol is a prodrug that undergoes rapid hydroxylation in the liver to form calcitriol (1,25-dihydroxyvitamin D3), bypassing the need for renal activation. This unique metabolic pathway makes it particularly valuable for patients with compromised kidney function, where the natural conversion of vitamin D to its active form is impaired. Administered parenterally, Epialfa ensures swift and consistent absorption, which is crucial in clinical scenarios demanding a rapid therapeutic response or when oral absorption is unreliable. It plays a pivotal role in maintaining robust bone health, preventing and treating hypocalcemia, and managing various conditions characterized by disturbances in calcium and phosphate homeostasis, thereby supporting overall skeletal integrity and metabolic balance.

Uses

• Management of hypocalcemia.
• Treatment of renal osteodystrophy.
• Prevention of osteoporosis in certain patient populations.
• Correction of vitamin D deficiency in malabsorption syndromes.

Directions For Use

Administer as directed by a healthcare professional, typically via intramuscular or intravenous injection. Do not self-administer.

Benefits

• Rapid onset of action.
• Effective in patients with renal impairment.
• Improves calcium and phosphate balance.
• Supports bone mineralization and strength.
• Reduces risk of fractures.
• Enhances overall bone health.

Side Effects

• Hypercalcemia
• Hyperphosphatemia
• Nausea
• Vomiting
• Constipation
• Abdominal pain
• Headache
• Dizziness
• Muscle weakness
• Fatigue
• Increased thirst
• Frequent urination

Safety Measures

• Alcohol - Alcohol consumption should be limited as it may interfere with calcium metabolism and potentially exacerbate side effects.
• Pregnancy - Use with caution; benefits must outweigh risks. High doses may be teratogenic. Consult a doctor.
• Breastfeeding - Small amounts may pass into breast milk. Monitor infant for signs of hypercalcemia. Consult a doctor.
• Liver - Generally safe, but monitor liver function in prolonged use. Dose adjustment may be needed in severe impairment.
• Kidney - Particularly beneficial in renal impairment, but monitor calcium and phosphate levels closely to avoid hypercalcemia.
• Lung - No specific contraindications, but monitor for systemic effects that could indirectly impact respiratory function.

Disclaimer

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