Epirubitec 50mg Injection

About

Epirubicin, an anthracycline antineoplastic agent, functions primarily as a topoisomerase II inhibitor, playing a crucial role in the treatment of various solid tumors. Its mechanism of action involves intercalation into DNA, which disrupts DNA replication and transcription, alongside the inhibition of topoisomerase II, an enzyme vital for DNA unwinding and re-ligation during replication. Furthermore, epirubicin generates free radicals, contributing to oxidative stress and cellular damage. These combined actions lead to significant DNA damage, ultimately inducing apoptosis and inhibiting the proliferation of rapidly dividing cancer cells. Epirubitec 50mg Injection is administered intravenously, with the precise dosage and schedule tailored to the specific cancer type, disease stage, and individual patient factors, including their bone marrow function, hepatic status, and prior chemotherapy exposure. It is a cornerstone in many multi-drug chemotherapy regimens.

Uses

• Treatment of breast cancer.
• Management of gastric cancer.
• Therapy for ovarian cancer.
• Treatment of small cell lung cancer.

Directions For Use

Administer intravenously as directed by a healthcare professional. Dosage and infusion rate are determined by the physician based on the patient's condition.

Benefits

• Effective against a broad spectrum of solid tumors.
• Can be used in neoadjuvant, adjuvant, and palliative settings.
• May improve disease-free survival in certain cancers.
• Part of established combination chemotherapy protocols.
• Available in various strengths for flexible dosing.
• Administered by healthcare professionals ensuring proper technique.

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Alopecia (hair loss)
• Mucositis/Stomatitis
• Cardiotoxicity (heart damage)
• Fatigue and weakness
• Diarrhea
• Anorexia
• Hyperpigmentation of skin/nails
• Injection site reactions
• Amenorrhea
• Secondary malignancies

Safety Measures

• Alcohol - Avoid alcohol consumption as it may exacerbate gastrointestinal side effects and potentially increase liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to significant risk of fetal harm and teratogenicity. Effective contraception is required during treatment.
• Breastfeeding - Not recommended during breastfeeding as the drug is likely excreted in breast milk and can cause serious adverse effects in the infant.
• Liver - Use with caution and dose adjustment in patients with impaired liver function, as hepatic impairment can increase drug exposure and toxicity.
• Kidney - Generally safe in mild to moderate renal impairment, but caution is advised in severe cases; dose adjustments may be necessary.
• Lung - While not a primary target organ for toxicity, patients with pre-existing lung conditions should be monitored for any respiratory complications.

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