Erlogis 100mg Capsule

About

Erlotinib is an orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, primarily utilized in the treatment of specific types of cancer. Its mechanism of action involves selectively blocking the intracellular phosphorylation of tyrosine kinases associated with the EGFR, a protein frequently overexpressed or mutated in various malignancies, most notably non-small cell lung cancer (NSCLC). By inhibiting EGFR, erlotinib effectively disrupts crucial downstream signaling pathways that regulate cell growth, proliferation, angiogenesis, and survival, thereby impeding tumor progression and metastasis.

This targeted therapeutic approach differentiates it from traditional cytotoxic chemotherapy, often leading to a more specific spectrum of clinical responses and adverse events. It is commonly indicated for patients with advanced or metastatic NSCLC who harbor specific EGFR activating mutations, or in combination with gemcitabine for the treatment of locally advanced, unresectable, or metastatic pancreatic cancer, aiming to enhance progression-free survival and overall patient outcomes.

Uses

• Treatment of advanced or metastatic non-small cell lung cancer (NSCLC).
• Maintenance therapy for NSCLC after initial chemotherapy.
• Treatment of pancreatic cancer in combination with gemcitabine.
• Used in patients with specific EGFR mutations.

Directions For Use

Take orally, usually once daily, on an empty stomach at least one hour before or two hours after food. Follow your doctor's prescribed dosage and schedule.

Benefits

• Targets specific cancer pathways, leading to more precise treatment.
• Can improve progression-free survival in eligible patients.
• Available as an oral tablet, offering convenience.
• May be effective in patients who have failed other therapies.
• Reduces tumor growth and spread in sensitive cancers.
• Potentially extends overall survival in specific patient populations.

Side Effects

• Diarrhea
• Skin rash (acne-like)
• Nausea and vomiting
• Fatigue
• Loss of appetite
• Dry skin
• Conjunctivitis
• Stomatitis
• Hair thinning
• Abdominal pain
• Interstitial lung disease (rare but serious)
• Liver enzyme elevation

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate liver side effects or gastrointestinal irritation.
• Pregnancy - Not recommended during pregnancy due to potential fetal harm. Effective contraception is advised for women of childbearing potential.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with pre-existing liver impairment; dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Generally considered safe in mild to moderate renal impairment; however, caution and monitoring are advised in severe kidney disease.
• Lung - Use with extreme caution in patients with pre-existing lung conditions due to the rare but serious risk of interstitial lung disease.

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