Erlotirel 100mg Tablet

About

Erlotirel 100mg Tablet is an oral targeted therapy medication classified as a tyrosine kinase inhibitor. It specifically targets the epidermal growth factor receptor (EGFR), a protein found on the surface of many cancer cells that plays a crucial role in cell growth and division. By inhibiting EGFR, Erlotirel interferes with the signaling pathways that promote tumor cell proliferation, survival, and metastasis. This selective action makes it an effective treatment for certain types of cancer that exhibit EGFR mutations or overexpression.

This medication is primarily indicated for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer, particularly in patients whose tumors have specific EGFR mutations or who have progressed after initial chemotherapy. Erlotirel is taken orally, typically once daily, and its efficacy is often evaluated through molecular testing to identify appropriate patient populations. Due to its targeted mechanism, it offers a different therapeutic approach compared to conventional chemotherapy, often with a distinct side effect profile. Close monitoring for adverse events, especially dermatological and gastrointestinal, is essential during treatment.

Uses

• Treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating EGFR mutations.
• Maintenance treatment for patients with advanced NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.
• Treatment of locally advanced, unresectable, or metastatic pancreatic cancer in combination with gemcitabine.
• Second-line treatment for advanced NSCLC after failure of at least one prior chemotherapy regimen.

Directions For Use

Take one tablet orally once daily, at least one hour before or two hours after food. Follow your doctor's instructions.

Benefits

• Targets specific cancer-driving pathways (EGFR).
• Effective in certain types of non-small cell lung cancer.
• Can improve progression-free survival in selected patients.
• Offers an oral, convenient dosing regimen.
• May be used as first-line, maintenance, or second-line therapy.
• Provides a targeted alternative to traditional chemotherapy.

Side Effects

• Rash (acneiform dermatitis).
• Diarrhea.
• Nausea and vomiting.
• Fatigue.
• Loss of appetite.
• Dry skin.
• Conjunctivitis.
• Stomatitis (mouth sores).
• Liver enzyme elevations.
• Interstitial lung disease (rare but serious).
• Gastrointestinal perforation (rare).
• Kidney dysfunction.

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate liver-related side effects or interact with the medication.
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm. Women of childbearing potential must use effective contraception.
• Breastfeeding - Contraindicated during breastfeeding as it is unknown if it passes into breast milk and could harm the infant.
• Liver - Use with caution in patients with hepatic impairment. Liver function should be monitored regularly.
• Kidney - Use with caution in patients with severe renal impairment. No specific dosage adjustment is typically needed for mild to moderate impairment.
• Lung - Patients should be monitored for new or worsening pulmonary symptoms, as interstitial lung disease is a rare but serious side effect.

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