Erubin 10mg Injection

About

Erubin 10mg Injection contains Epirubicin, an anthracycline topoisomerase II inhibitor, which is a potent antineoplastic agent used in the treatment of various cancers. Its mechanism of action involves several pathways: it intercalates into DNA, inhibits topoisomerase II, and generates free radicals, all contributing to DNA damage and subsequent cell death. Epirubicin is particularly effective against breast cancer, lymphomas, and gastric cancer, often forming a critical component of multi-drug chemotherapy regimens.

Administered intravenously, Epirubicin's cytotoxic effects are dose-dependent and target rapidly dividing cells. While highly effective, its use is associated with potential side effects, most notably dose-dependent cardiotoxicity and myelosuppression, requiring careful patient monitoring. The drug's distinct red color is due to its anthracycline structure, which can cause harmless red discoloration of urine. Its established efficacy and broad spectrum of activity make it a valuable agent in modern oncology.

Uses

• Adjuvant treatment of breast cancer
• Metastatic breast cancer
• Lymphomas
• Gastric cancer

Directions For Use

This injection is administered intravenously by a healthcare professional, typically as a short infusion. Do not self-administer.

Benefits

• Broad-spectrum anti-cancer activity
• Key component in many chemotherapy regimens
• Effective against various solid tumors and hematologic malignancies
• Improves disease-free and overall survival rates
• Can be used effectively in combination therapy
• Well-established efficacy and safety profile

Side Effects

• Bone marrow suppression (myelosuppression)
• Nausea and vomiting
• Hair loss (alopecia)
• Fatigue
• Mouth sores (stomatitis)
• Diarrhea
• Cardiotoxicity (dose-dependent)
• Red urine (harmless discoloration)
• Injection site reactions
• Allergic reactions
• Secondary malignancies (rare, long-term risk)
• Amenorrhea

Safety Measures

• Alcohol - Avoid alcohol consumption due to potential for increased gastrointestinal irritation and liver strain.
• Pregnancy - Contraindicated during pregnancy as it can cause fetal harm. Use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and harm the infant.
• Liver - Contraindicated in severe hepatic impairment; dosage adjustment needed in moderate impairment.
• Kidney - Use with caution; dosage adjustment may be necessary in patients with renal impairment.
• Lung - Rarely, interstitial pneumonitis can occur; monitor for new or worsening respiratory symptoms.

Disclaimer

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