Glycinorm M 60 Od Tab

About

Glycinorm M 60 OD Tab is a combination medication used in the management of Type 2 Diabetes Mellitus. It contains Gliclazide, a sulfonylurea, and Metformin, a biguanide. Gliclazide works by stimulating the beta cells of the pancreas to release more insulin, thereby lowering blood glucose levels. Metformin, on the other hand, primarily reduces glucose production by the liver, decreases glucose absorption from the intestines, and improves the body's sensitivity to insulin. This dual mechanism of action provides comprehensive glycemic control, making it effective for patients whose blood sugar levels are not adequately controlled by diet, exercise, or monotherapy with either agent alone. The "OD" in the name suggests an once-daily, extended-release formulation, designed to provide sustained therapeutic effects throughout the day, contributing to better patient adherence and stable glucose management.

Uses

• Management of Type 2 Diabetes Mellitus.
• Improvement of glycemic control in adults.
• When diet and exercise alone are insufficient.
• When monotherapy with Gliclazide or Metformin is inadequate.

Directions For Use

Take this medication exactly as prescribed by your doctor, usually once daily with food. Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Provides effective blood sugar control.
• Reduces elevated HbA1c levels.
• Offers a dual mechanism of action for comprehensive management.
• Convenient once-daily dosing (OD formulation).
• Helps prevent long-term diabetic complications.
• May contribute to modest weight management (due to Metformin).

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Metallic taste in mouth
• Headache
• Dizziness
• Skin rash or itching
• Lactic acidosis (rare but serious)
• Vitamin B12 deficiency (with long-term use)
• Weight gain (less common with Metformin combination)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can increase the risk of hypoglycemia (low blood sugar) and may also heighten the risk of lactic acidosis, a rare but serious side effect, especially with Metformin.
• Pregnancy - Generally not recommended during pregnancy. Insulin is typically preferred for managing diabetes in pregnant women. Consult your doctor for appropriate management.
• Breastfeeding - Both Gliclazide and Metformin can pass into breast milk. It is generally not recommended during breastfeeding. Discuss with your doctor to weigh the benefits and risks.
• Liver - Use with caution in patients with liver impairment. Metformin is contraindicated in severe hepatic dysfunction due to an increased risk of lactic acidosis. Liver function should be monitored.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to the risk of Metformin accumulation and lactic acidosis. Dose adjustments are necessary for moderate impairment, and kidney function should be regularly assessed.
• Lung - Use with caution in conditions causing severe hypoxia (e.g., severe respiratory failure) as this can increase the risk of lactic acidosis, particularly with the Metformin component.

Disclaimer

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