Inflixirel 100mg Injection

About

Inflixirel 100mg Injection contains Infliximab, a chimeric monoclonal antibody that specifically targets and neutralizes tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a key cytokine involved in the inflammatory processes of various autoimmune diseases, including Crohn's disease, ulcerative colitis, rheumatoid arthritis, and psoriatic arthritis. By binding to both soluble and transmembrane forms of TNF-alpha, Infliximab prevents its interaction with cell surface receptors, thereby reducing inflammation and modulating the immune response. This therapeutic action helps to alleviate symptoms, slow disease progression, and improve the overall quality of life for patients suffering from chronic inflammatory conditions. It is typically administered intravenously in a clinical setting under medical supervision, often reserved for patients who have not responded adequately to conventional therapies. Its potent immunosuppressive effects require careful monitoring for potential side effects, particularly infections.

Uses

• Crohn's disease (moderate to severe)
• Ulcerative colitis (moderate to severe)
• Rheumatoid arthritis (moderate to severe)
• Psoriatic arthritis

Directions For Use

Administered intravenously by a healthcare professional. The dosage and frequency are tailored to the specific condition and patient's response, typically involving an induction phase followed by maintenance doses.

Benefits

• Significantly reduces inflammation
• Alleviates chronic pain and swelling
• Promotes mucosal healing in IBD
• Improves joint function and mobility
• Slows disease progression in autoimmune conditions
• Enhances overall quality of life

Side Effects

• Infusion-related reactions (fever, chills, rash)
• Headache
• Nausea
• Abdominal pain
• Upper respiratory tract infections
• Fatigue
• Rash or itching
• Increased risk of serious infections (e.g., tuberculosis)
• Development of autoantibodies
• Liver enzyme elevations
• Heart failure exacerbation
• Demyelinating disorders

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but excessive alcohol use can worsen underlying liver conditions, which may be relevant for some patients on infliximab.
• Pregnancy - Use during pregnancy is generally not recommended unless the potential benefit outweighs the potential risk to the fetus. Consult a doctor.
• Breastfeeding - Small amounts may pass into breast milk. The decision to breastfeed should consider the drug's necessity for the mother and potential risks to the infant.
• Liver - Use with caution in patients with pre-existing liver conditions. Liver function tests should be monitored regularly.
• Kidney - No specific dose adjustment is typically required for kidney impairment, but caution is advised in severe cases.
• Lung - Use with caution in patients with pre-existing lung conditions, especially those with chronic obstructive pulmonary disease (COPD) or a history of tuberculosis.

Disclaimer

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