Irnocam 100mg Injection

About

Irnocam 100mg Injection contains Irinotecan, a potent antineoplastic agent that acts as a topoisomerase I inhibitor. Its primary mechanism involves binding to the topoisomerase I-DNA complex, which prevents the re-ligation of DNA single-strand breaks. This interference leads to significant DNA damage, ultimately triggering cell cycle arrest and programmed cell death (apoptosis) in rapidly dividing cancer cells. Irinotecan is a prodrug that is converted into its active metabolite, SN-38, which is considerably more potent. It is widely used in the treatment of various advanced solid tumors, often as a component of multi-drug chemotherapy regimens. Administration is strictly via intravenous infusion under close medical supervision. Due to its notable toxicity profile, including severe myelosuppression and delayed diarrhea, meticulous patient monitoring and comprehensive supportive care are essential throughout the treatment period.

Uses

• Metastatic colorectal cancer
• Pancreatic cancer
• Lung cancer (small cell and non-small cell)
• Gastric cancer

Directions For Use

Administered intravenously by a qualified healthcare professional. Do not attempt self-administration.

Benefits

• Effective against various advanced solid tumors.
• Can extend survival in metastatic colorectal cancer.
• Often used in combination regimens for enhanced efficacy.
• Provides a treatment option for refractory cancers.
• Helps to control tumor growth and progression.
• May improve disease-free survival.

Side Effects

• Severe diarrhea (early and late onset)
• Myelosuppression (neutropenia, anemia, thrombocytopenia)
• Nausea and vomiting
• Abdominal cramps
• Hair loss (alopecia)
• Fatigue
• Fever
• Cholinergic syndrome (rhinitis, lacrimation, salivation)
• Stomatitis
• Anorexia
• Elevated liver enzymes
• Dehydration

Safety Measures

• Alcohol - Avoid alcohol during treatment as it can exacerbate gastrointestinal side effects and liver strain.
• Pregnancy - Contraindicated in pregnancy due to severe fetal toxicity; use highly effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug can pass into breast milk and harm the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are crucial and monitoring is essential.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary based on kidney function.
• Lung - Monitor for rare but serious pulmonary toxicities like interstitial lung disease; report any new respiratory symptoms.

Disclaimer

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