Irnotop 40mg Injection

About

Irnotop 40mg Injection contains Irinotecan, a potent antineoplastic agent belonging to the class of topoisomerase I inhibitors. It functions by binding to the topoisomerase I-DNA complex, preventing the re-ligation of DNA single-strand breaks and leading to DNA damage. This ultimately results in cell cycle arrest and apoptosis in rapidly proliferating cancer cells. Irinotecan is a prodrug that is converted to its active metabolite, SN-38, which is significantly more potent. It is primarily used in the treatment of various solid tumors, often in combination with other chemotherapeutic agents. Administration is typically via intravenous infusion under strict medical supervision. Due to its significant toxicity profile, including severe myelosuppression and diarrhea, careful patient monitoring and supportive care are essential throughout the treatment course.

Uses

• Metastatic colorectal cancer
• Pancreatic cancer
• Lung cancer (small cell and non-small cell)
• Gastric cancer

Directions For Use

Administered intravenously by a qualified healthcare professional. Do not attempt self-administration.

Benefits

• Effective against various advanced solid tumors.
• Can extend survival in metastatic colorectal cancer.
• Often used in combination regimens for enhanced efficacy.
• Provides a treatment option for refractory cancers.
• Helps to control tumor growth and progression.
• May improve disease-free survival.

Side Effects

• Severe diarrhea (early and late onset)
• Myelosuppression (neutropenia, anemia, thrombocytopenia)
• Nausea and vomiting
• Abdominal cramps
• Hair loss (alopecia)
• Fatigue
• Fever
• Cholinergic syndrome (rhinitis, lacrimation, salivation)
• Stomatitis
• Anorexia
• Elevated liver enzymes
• Dehydration

Safety Measures

• Alcohol - Avoid alcohol during treatment as it can exacerbate gastrointestinal side effects and liver strain.
• Pregnancy - Contraindicated in pregnancy due0 to severe fetal toxicity; use highly effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug can pass into breast milk and harm the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are crucial and monitoring is essential.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary based on kidney function.
• Lung - Monitor for rare but serious pulmonary toxicities like interstitial lung disease; report any new respiratory symptoms.

Disclaimer

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