Irnotop 100mg Injection

About

Irnotop 100mg Injection contains Irinotecan, a potent antineoplastic agent classified as a topoisomerase I inhibitor. Its mechanism of action involves binding to the topoisomerase I-DNA complex, which prevents the re-ligation of DNA single-strand breaks, leading to irreversible DNA damage. This ultimately triggers cell cycle arrest and programmed cell death (apoptosis) in rapidly dividing cancer cells. Irinotecan is a prodrug that undergoes metabolic activation to its highly potent metabolite, SN-38. It is primarily utilized in the treatment of various advanced solid tumors, often as part of a combination chemotherapy regimen. Administration is strictly via intravenous infusion under close medical supervision. Due to its significant toxicity profile, particularly severe myelosuppression and delayed diarrhea, meticulous patient monitoring and comprehensive supportive care are paramount throughout the treatment period.

Uses

• Metastatic colorectal cancer
• Pancreatic cancer
• Lung cancer (small cell and non-small cell)
• Gastric cancer

Directions For Use

Administered intravenously by a qualified healthcare professional. Do not attempt self-administration.

Benefits

• Effective against various advanced solid tumors.
• Can extend survival in metastatic colorectal cancer.
• Often used in combination regimens for enhanced efficacy.
• Provides a treatment option for refractory cancers.
• Helps to control tumor growth and progression.
• May improve disease-free survival.

Side Effects

• Severe diarrhea (early and late onset)
• Myelosuppression (neutropenia, anemia, thrombocytopenia)
• Nausea and vomiting
• Abdominal cramps
• Hair loss (alopecia)
• Fatigue
• Fever
• Cholinergic syndrome (rhinitis, lacrimation, salivation)
• Stomatitis
• Anorexia
• Elevated liver enzymes
• Dehydration

Safety Measures

• Alcohol - Avoid alcohol during treatment as it can exacerbate gastrointestinal side effects and liver strain.
• Pregnancy - Contraindicated in pregnancy due to severe fetal toxicity; use highly effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug can pass into breast milk and harm the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are crucial and monitoring is essential.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary based on kidney function.
• Lung - Monitor for rare but serious pulmonary toxicities like interstitial lung disease; report any new respiratory symptoms.

Disclaimer

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