JUSLINA DM 5/500 TAB

About

Juslina DM 5/500 combines Dapagliflozin (5mg) and Metformin (500mg), offering a dual-action approach for the management of type 2 diabetes mellitus. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine and subsequently lowering blood glucose levels. Metformin, a biguanide, reduces hepatic glucose production and improves insulin sensitivity.

This combination medication is particularly effective for patients who have not achieved adequate glycemic control with metformin alone or who require additional benefits such as weight reduction and cardiovascular protection, which are associated with SGLT2 inhibitors. The synergistic effects of these two agents provide comprehensive blood sugar management, helping to reduce HbA1c and improve overall metabolic health.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control in adults.
• Reduction of HbA1c levels.
• Used when diet and exercise alone are insufficient.

Directions For Use

Take this medicine orally, usually twice daily with meals, or as directed by your healthcare provider. Swallow the tablet whole with water; do not crush, chew, or break it.

Benefits

• Provides dual mechanism for blood glucose control.
• Effectively lowers fasting and postprandial glucose.
• May lead to modest weight loss.
• Offers cardiovascular and renal benefits (from dapagliflozin).
• Improves insulin sensitivity.
• Reduces the risk of hypoglycemia compared to insulin secretagogues.

Side Effects

• Genital yeast infections
• Urinary tract infections
• Increased urination
• Nausea
• Diarrhea
• Abdominal pain
• Metallic taste
• Dizziness
• Fatigue
• Dehydration
• Ketoacidosis (rare, SGLT2 specific)
• Lactic acidosis (rare, metformin specific)

Safety Measures

• Alcohol - Limit alcohol intake as it can increase the risk of lactic acidosis (due to metformin) and may also affect blood sugar levels.
• Pregnancy - Not recommended during the second and third trimesters due to potential fetal renal dysfunction. Consult your doctor for alternative treatments.
• Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk and their effects on the infant are not fully established.
• Liver - Use with caution in patients with liver impairment due to the metformin component, which increases the risk of lactic acidosis. Not recommended in severe hepatic dysfunction.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment or discontinuation may be necessary based on kidney function due to both components.
• Lung - Generally safe for use in patients with lung conditions. However, conditions causing hypoxia may increase lactic acidosis risk (metformin), so caution is advised.

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