Lanolimus 0.25mg Tablet

About

Tacrolimus is a potent immunosuppressant belonging to the calcineurin inhibitor class, primarily used to prevent organ rejection in transplant recipients. Its mechanism of action involves binding to an intracellular protein, FKBP-12, forming a complex that inhibits calcineurin. This inhibition prevents the dephosphorylation of nuclear factor of activated T-cells (NFAT), thereby blocking the transcription of genes encoding pro-inflammatory cytokines like interleukin-2 (IL-2). The ultimate effect is a profound suppression of T-lymphocyte activation and proliferation, which is crucial for preventing the immune system from attacking the transplanted organ. It is also used in certain autoimmune conditions where immune suppression is beneficial.

Uses

• Prevention of organ rejection (kidney, liver, heart)
• Treatment of refractory organ rejection
• Management of certain autoimmune diseases
• Topical use for severe atopic dermatitis

Directions For Use

Take this tablet orally, usually twice daily, on an empty stomach (1 hour before or 2-3 hours after a meal) to ensure consistent absorption. Swallow whole with water.

Benefits

• Highly effective in preventing organ transplant rejection.
• Reduces the need for higher doses of corticosteroids.
• Improves long-term graft survival rates.
• Available in various formulations for tailored therapy.
• Can be used in combination with other immunosuppressants.
• Helps maintain the function of transplanted organs.

Side Effects

• Tremor
• Headache
• Hypertension
• Diarrhea
• Nausea
• Kidney dysfunction (nephrotoxicity)
• Increased blood sugar (hyperglycemia)
• Insomnia
• Infections (due to immunosuppression)
• Electrolyte disturbances (e.g., hyperkalemia)
• Hair loss (alopecia)
• Peripheral edema

Safety Measures

• Alcohol - Avoid or limit alcohol as it can increase the risk of liver toxicity and exacerbate side effects like tremor or headache.
• Pregnancy - Tacrolimus can cross the placenta and may cause fetal harm. Use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding - Tacrolimus is excreted in breast milk and is not recommended during breastfeeding due to potential adverse effects on the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments are often necessary, and liver function should be closely monitored.
• Kidney - Tacrolimus is nephrotoxic; close monitoring of kidney function and dose adjustments are crucial, especially in patients with pre-existing renal conditions.
• Lung - Rarely, interstitial lung disease or pulmonary fibrosis can occur. Monitor for new or worsening respiratory symptoms.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.